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Differential production of type I IFN determines the reciprocal levels of IL-10...

Howes, Ashleigh; Taubert, Christina; Blankley, Simon; Spink, Natasha; Wu, Xuemei; Graham, Christine M.; Zhao, Jiawen; Saraiva, Margarida

Pattern recognition receptors detect microbial products and induce cytokines, which shape the immunological response. IL-12, TNF-alpha, and IL-1 beta are proinflammatory cytokines, which are essential for resistance against infection, but when produced at high levels they may contribute to immunopathology. In contrast, IL-10 is an immunosuppressive cytokine, which dampens proinflammatory responses, but it can a...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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