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Mapeamento dos determinantes estruturais da proteína Rtg2p, envolvidos na sinal...
Bleicher, Lucas
Using Amino Acid Correlation and Community Detection Algorithms to Identify Fun...
Bleicher, Lucas; Lemke, Ney [UNESP]; Garratt, Richard CharlesMade available in DSpace on 2013-08-28T14:09:29Z (GMT). No. of bitstreams: 1 WOS000298666200001.pdf: 402150 bytes, checksum: 3723ce8567931f389f45074a49611911 (MD5); Made available in DSpace on 2013-09-30T18:37:20Z (GMT). No. of bitstreams: 2 WOS000298666200001.pdf: 402150 bytes, checksum: 3723ce8567931f389f45074a49611911 (MD5) WOS000298666200001.pdf.txt: 56655 bytes, checksum: 10d0e581654ecca834117e332f3f69ca (...
Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms
Bleicher, Lucas; Aparicio, Ricardo; Nunes, Fábio Macêdo; Martínez, Leandro; Dias, Sandra Martha Gomes; Figueira, Ana Carolina MiglioriniBackground: Thyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level and heart activities. Whereas metabolism increase and cholesterol level lowering could be achieved by TRβ isoform activation, TRα activation affects heart rates. Therefore, β-selective thyromimetics have been developed as promising drug-candidates for treatment of obesity and eleva...