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Linking bioaccessibility and carotenoids to antioxidant activity in diatoms

Rocha, Helena R.; Coelho, Marta; Coelho, Natacha; Morais, Rui M. S. C.; Pintado, Manuela; Gomes, Ana M.

Diatoms are photosynthetic microalgae with a siliceous cell wall and remarkable adaptability, making them a sustainable and renewable resource for high-value bioactive compounds (1,2). Their rapid growth, efficient carbon fixation, and minimal land and freshwater requirements (1,2) position them as attractive candidates for the development of eco-friendly products in the nutraceutical, pharmaceutical, and cosme...


Bioactive profile, bioaccessibility and antioxidant activity of diatoms: a comp...

Rocha, Helena R.; Coelho, Marta; Coelho, Natacha; Morais, Rui M. S. C.; Pintado, Manuela E.; Gomes, Ana M.

Diatoms are microalgae with significant biotechnological potential due to their richness in bioactive compounds, including carotenoids and phenolics, contributing to their antioxidant properties. This study aims to compare the bioactive profile and antioxidant activity of three diatom species: Chaetoceros calcitrans, Nannofrustulum shiloi, and Cylindrotheca fusiformis cultivated in closed Flat Panel photobiorea...


From lignocellulosic residues to protein sources: insights into biomass pre-tre...

Vera dos Anjos, Isabela; Coelho, Natacha; Duarte, Hugo; Proença, Diogo Neves; Duarte, Maria F.; Jorge de Barros, Raúl José; Raposo, Sara

With the global population steadily rising, the demand for sustainable protein sources has become increasingly urgent. Traditional animal- and plant-based proteins face challenges related to scalability, resource efficiency, and environmental impact. In this context, single-cell protein has emerged as a promising alternative. Derived from microorganisms such as algae, bacteria, fungi, and yeast, single-cell pro...


Culturable yeast diversity associated with industrial cultures of the microalga...

Matos, Madalena; Fernandes, Mónica A.; Costa, Inês; Coelho, Natacha; Santos, Tamara; Rossetto, Veronica; Varela, João; Sá-Correia, Isabel

The marine oleaginous microalga Microchloropsis gaditana (formerly Nannochloropsis gaditana) exhibits a high capacity to thrive in a broad range of environmental conditions, being predominantly utilized as feed in aquaculture. This article reports the characterization of the culturable yeast population present during the scale-up process of M. gaditana cultivation at Necton S.A. facilities, from 5 L flasks unti...


Yeast species associated with industrial cultures of the marine microalgae Tiso...

Matos, Madalena; Fernandes, Mónica A.; Coelho, Natacha; Santos, Tamara; Varela, João; Rodrigues, Alexandre M. C.; Sá-Correia, Isabel

This study provides the first systematic characterization of culturable yeast diversity associated with large-scale cultivation of Tisochrysis lutea. This marine haptophyte is widely used in aquaculture for its high content of essential fatty acids, pigments, and other bioactive compounds. Culture sampling was conducted at Necton S.A. facilities (Olhão, Portugal) over full production cycles from 5 L flasks unti...


Comparative analysis of isoprostanoid profiles in Chlorella sorokiniana grown u...

Conde, Tiago; Lopes, Diana; Gros, Valérie; Reversat, Guillaume; Oger, Camille; Galano, Jean-Marie; Vigor, Claire; Rodrigues, Alexandre M. C.

Oxylipins are bioactive lipid mediators derived from polyunsaturated fatty acids (PUFAs), with roles in oxidative stress responses, immunomodulation, and inflammation. While microalgae are recognized as valuable sources of oxylipins, their profiles remain less studied across different species and cultivation conditions. In this study, we characterized the non-enzymatic oxylipin profile of Chlorella sorokiniana ...


Yeast species associated with industrial cultures of the marine microalgae tiso...

Matos, Madalena; Fernandes, Mónica A.; Coelho, Natacha; Santos, Tamara; Varela, João; Rodrigues, Alexandre M. C.; Sá-Correia, Isabel

This study provides the first systematic characterization of culturable yeast diversity associated with large-scale cultivation of Tisochrysis lutea. This marine haptophyte is widely used in aquaculture for its high content of essential fatty acids, pigments, and other bioactive compounds. Culture sampling was conducted at Necton S.A. facilities (Olhão, Portugal) over full production cycles from 5 L flasks unti...


Nutritional profiling and stability analysis of selected microalgae

Rocha, Helena R.; Coelho, Marta; Coelho, Natacha; Morais, Rui; Pintado, Manuela E.; Gomes, Ana M.

Microalgae are emerging as a valuable source of nutrients and bioactive compounds1, offering substantial potential for applications in food2. This study provides a comprehensive biochemical characterisation of several microalgae species, including Chaetoceros calcitrans, Cylindrotheca fusiformis, and Nannofrustulum shiloi, focusing on protein content, mineral composition, amino acid profile, and shelf-life stab...


Carotenoid-microbiota dynamics: in vitro analysis of gut modulation and associa...

Rocha, Helena R.; Coelho, Marta; Coelho, Natacha; Morais, Rui M.S.C.; Pintado, Manuela E.; Gomes, Ana M.

Carotenoids are bioactive compounds with recognized health benefits, yet their full potential is limited by poor bioaccessibility and complex interactions within the gastrointestinal tract. This study aimed to investigate the digestion, absorption, and gut microbiota modulation of three carotenoids (β-carotene, lutein, lycopene), a mixed carotenoid solution, and the red alga Osmundea pinnatifida. Using a simula...


The Mediterranean diet: fostering a common vision through a multidisciplinary a...

Delgado, Amélia; Cruz, Ana Lúcia; Coelho, Natacha; Romano, Anabela

Inscribed in the UN’s Representative List of the Intangible Cultural Heritage of Humanity, the Mediterranean Diet (MD) is intrinsic to the Mediterranean identity. It involves a set of skills, knowledge, rituals, symbols and traditions related to cultures, landscape and lifestyle. Nevertheless, some Mediterranean rural regions seem to have natural and demographic handicaps resulting from ignorance of the economi...


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