2 documents found, page 1 of 1
Real-world EGFR testing practices for non-small-cell lung cancer by thoracic pa...
Hofman, P; Calabrese, F; Kern, I; Adam, J; Alarcão, A.; Alborelli, I; Anton, N T; Arndt, A; Avdalyan, A; Barberis, M; Bégueret, H; Bisig, B; Blons, HBackground: Testing for epidermal growth factor receptor (EGFR) mutations is an essential recommendation in guidelines for metastatic non-squamous non-small-cell lung cancer, and is considered mandatory in European countries. However, in practice, challenges are often faced when carrying out routine biomarker testing, including access to testing, inadequate tissue samples and long turnaround times (TATs). Mater...
Simultaneous detection of lung fusions using a multiplex RT-PCR next generation...
Vaughn, C; Costa, JL; Feilotter, H; Petraroli, R; Bagai, V; Rachiglio, A; Marino, F; Tops, B; Kurth, H; Sakai, K; Mafficini, A; Bastien, R; Reiman, ABackground: Gene fusion events resulting from chromosomal rearrangements play an important role in initiation of lung adenocarcinoma. The recent association of four oncogenic driver genes, ALK, ROS1, RET, and NTRK1, as lung tumor predictive biomarkers has increased the need for development of up-to-date technologies for detection of these biomarkers in limited amounts of material. Methods: We describe here a mu...