15 documents found, page 1 of 2

Autophagy buffers Ras-induced genotoxic stress enabling malignant transformatio...

Made available in DSpace on 2022-04-29T08:45:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Malignant transformation involves an orchestrated rearrangement of cell cycle regulation mechanisms that must balance autonomic mitogenic impulses and deleterious oncogenic stress. Human papillomavirus (HPV) infection is highly preval...

ATM pathway is essential for HPV–positive human cervical cancer-derived cell li...

Antiviral activity of curcumin-nanoemulsion associated with photodynamic therap...

Made available in DSpace on 2020-12-12T02:35:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Vulvar intraepithelial neoplasia (VIN) is associated with human papillomavirus (HPV) infection. Curcumin is a natural bioactive compound with antineoplastic properties. The use of nanoparticles containing curcumin could allow a better perfor...

HPV-mediated resistance to TNF and TRAIL is characterized by global alterations...

Three Prime Repair Exonuclease 1 (TREX1) expression correlates with cervical ca...

Alterations in specific DNA damage repair mechanisms in the presence of human papillomavirus (HPV) infection have been described in different experimental models. However, the global effect of HPV on the expression of genes involved in these pathways has not been analyzed in detail. In the present study, we compared the expression profile of 135 genes involved in DNA damage repair among primary human keratinocy...

Alterations in the expression and activity of extracellular matrix components i...

Infection with human papillomaviruses is associated with a series of benign and malignant hyperproliferative diseases that impose a heavy burden on human populations. A subgroup of mucosal human papillomavirus types are associated with the majority of cervical cancers and a relevant fraction of vulvar, vaginal, anal, penile and head and neck carcinomas. Human papillomaviruses mediate cell transformation by the ...

Human polyomaviruses and cancer: an overview

The name of the family Polyomaviridae, derives from the early observation that cells infected with murine polyomavirus induced multiple (poly) tumors (omas) in immunocompromised mice. Subsequent studies showed that many members of this family exhibit the capacity of mediating cell transformation and tumorigenesis in different experimental models. The transformation process mediated by these viruses is driven by...

Oxidative stress: therapeutic approaches for cervical cancer treatment

OBJECTIVES: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory responses and reactive oxygen species production. In th...

Human papillomavirus and genome instability: from productive infection to cancer

HPVInfection with high oncogenic risk human papillomavirus types is the etiological factor of cervical cancer and a major cause of other epithelial malignancies, including vulvar, vaginal, anal, penile and head and neck carcinomas. These agents affect epithelial homeostasis through the expression of specific proteins that deregulate important cellular signaling pathways to achieve efficient viral replication. A...

HPV16 E6 regulates annexin 1 (ANXA1) protein expression in cervical carcinoma c...

Made available in DSpace on 2018-11-26T16:54:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-09-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Annexin 1 (ANXA1) is a substrate for E6AP mediated ubiquitylation. It has been hypothesized that HPV 16 E6 protein redirects E6AP away from ANXA1, increasing its stability and possibly contributing to viral pathogenesis. We analyzed ANXA1 ex...