3 documents found, page 1 of 1
Toll-like receptor-1 single-nucleotide polymorphism 1805T/G is associated with ...
Barletta-Naveca, Raphaela Honorato; Naveca, Felipe Gomes; Almeida, Vanessa Alves de; Porto, Jorge Ivan Rebelo; Silva, George Allan Villarouco daTuberculosis (TB), caused by mycobacterial species of the Mycobacterium tuberculosis complex, is a serious global health issue. Brazil is among the 22 countries with the highest number of TB cases, and the state of Amazonas has the highest incidence of TB cases in the country. Toll-like receptors (TLRs) are important pattern recognition receptors of the innate immunity and play a key role in orchestrating an ef...
Interaction between smoking and HLA-DRB1*04 gene is associated with a high card...
Boechat, Narjara de Oliveira; Ogusku, Maurício Morishi; Boechat, Antonio Luiz; Sadahiro, AyaBackground: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints that affects approximately 1% of the population worldwide. The HLA-DRB1 gene locus plays a major role in genetic susceptibility to RA, a condition that has been associated with a high cardiovascular morbidity and mortality in many studies. Methodology/Principal Findings: The aim of this work was to...
Alleles of HLA-DRB1∗04 associated with pulmonary tuberculosis in Amazon Brazili...
Lima, Dhêmerson Souza de; Ogusku, Maurício Morishi; Santos, Maria Cristina dos; Silva, Cláudia Maria de Melo; Almeida, Vanessa Alves deImmunogenetic host factors are associated with susceptibility or protection to tuberculosis (TB). Strong associations of HLA class II genes with TB are reported. We analyzed the HLA-DRB1∗04 alleles to identify subtypes associated with pulmonary TB and their interaction with risk factors such as alcohol, smoking, and gender in 316 pulmonary TB patients and 306 healthy individuals from the Brazilian Amazon. The H...