18 documents found, page 1 of 2

Glucose metabolism as a potential therapeutic target in Cytarabine-resistant ac...

Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need clarification, as well as how to explore these metabolic alterations in therapy. In the present study, we aimed to elucidate the role of glucose metabolism in the acquired resistance of AML cells to cytarabine (Ara-C) and to explore it as a therapeutic target. Resist...

Frequency of Human Papillomavirus Detection in Chagasic Megaesophagus Associate...

Made available in DSpace on 2022-04-29T08:35:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Background: Chagasic megaesophagus (CM) as well as the presence of human papillomavirus (HPV) has been reported as etiological factors for esophageal squamous cell carcinoma (ESCC). Objective: We assessed the prevalence of HPV DNA in a series of ESCCs associated or not with CM. Data obtained were furthe...

Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Ca...

In colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage-cancer cell crosstalk. To unravel this, co-cultures of human primary macrophages and colon cancer cells were performed at 20% and 1% O2, followed by characterization of both cellular components. Different colon cancer patient cohorts were analyzed for hypoxia and immune markers, and th...

A 30-year long-term experience in appendix neuroendocrine neoplasms—granting a ...

Neuroendocrine neoplasms (NENs) are the most common tumor of the appendix and have an excellent prognosis. Appendiceal tumors diagnosed between 1989 and 2019 were reviewed, and clinical data were collected from patient files. Part of the series was immuno-profiled for markers related to cell cycle proliferation and/or senescence-type, apoptotic, and metastatic potential. Appendix NENs were detected in 74 patien...

Loss of 5 '-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade ...

Made available in DSpace on 2020-12-10T19:54:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Barretos Cancer Hospital; Public Ministry of Labor Campinas (Research, Prevention and Education of Occ...

The combination of coffee compounds attenuates early fibrosis-associated hepato...

Made available in DSpace on 2020-12-12T02:22:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-11-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Aberrant microRNA expression implicates on hepatocellular carcinoma (HCC) development. Conversely, coffee consumption reduces by ~40% the risk for fibrosis/cirrhosis and HCC, while decaffeinated coffee does not. It is currently unknown wheth...

WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line

Autophagy is a cell-survival pathway with dual role in tumorigenesis, promoting either tumor survival or tumor death. WNK2 gene, a member of the WNK (with no lysine (K)) subfamily, acts as a tumor suppressor gene in gliomas, regulating cell migration and invasion; however, its role in autophagy process is poorly explored. The WNK2-methylated human glioblastoma cell line A172 WT (wild type) was compared to trans...

Brachyury Is associated with glioma differentiation and response to temozolomide

Glioblastomas (GBMs) are the most aggressive tumor type of the central nervous system, mainly due to their high invasiveness and innate resistance to radiotherapy and chemotherapy, with temozolomide (TMZ) being the current standard therapy. Recently, brachyury was described as a novel tumor suppressor gene in gliomas, and its loss was associated with increased gliomagenesis. Here, we aimed to explore the role o...

Lack of KBTBD4 mutations in molecularly classified brazilian medulloblastomas

Relationship between fusobacterium nucleatum, inflammatory mediators and microR...

Made available in DSpace on 2019-10-06T16:11:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-21; Made available in DSpace on 2019-10-06T16:11:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-21; AIM To examine the effect of Fusobacterium nucleatum (F. nucleatum ) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs (miRNAs). METHODS Lev...