Background The management of antidiabetic therapy in people with type 2 diabetes (T2D) has evolved beyond gly‑ cemic control. In this context, Brazil and Portugal defned a joint panel of four leading diabetes societies to update the guideline published in 2020. Methods The panelists searched MEDLINE (via PubMed) for the best evidence from clinical studies on treating T2D and its cardiorenal complications. The p...
Made available in DSpace on 2022-04-29T08:39:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Purpose: To evaluate the association between acromegaly and pregnancy in terms of disease activity, maternal and fetal outcomes. Methods: This systematic review was conducted according to the Joanna Briggs Institute methodology for systematic reviews of etiology and risk. We focused on observational stu...
Made available in DSpace on 2022-04-29T08:29:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-07-01; Context: Artificial intelligence (AI), in particular machine learning (ML), may be used to deeply analyze biomarkers of response to first-generation somatostatin receptor ligands (fg-SRLs) in the treatment of acromegaly. Objective: To develop a prediction model of therapeutic response of acromegaly to f...
Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction,...
Orientador: Doris Rosenthal; Dissertação (mestrado) - Universidade Federal do Parana, Setor de Ciencias da Saude; Resumo: O objetivo do presente estudo foi avaliar o efeito do tratamento supressivo com levotiroxina em reduzir o tamanho de nódulos tireoideanos clinicamente solitários. Os critérios para inclusão dos pacientes no estudo foram: nódulo frio ou morno a cintilografia, neste ultimo caso suprimível com ...
Made available in DSpace on 2019-10-03T18:18:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-06-01; State Univ UNESP, Botucatu Med Sch, Botucatu, SP, Brazil; Fed Univ Sao Paulo UNIFESP, Sao Paulo, Brazil; Sempr Fed Univ Parana, Curitiba, Parana, Brazil; State Univ UNESP, Botucatu Med Sch, Botucatu, SP, Brazil
Made available in DSpace on 2019-10-03T18:18:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-06-01; State Univ UNESP, Botucatu Med Sch, Botucatu, SP, Brazil; Fed Univ Sao Paulo UNIFESP, Sao Paulo, Brazil; Sempr Fed Univ Parana, Curitiba, Parana, Brazil; State Univ UNESP, Botucatu Med Sch, Botucatu, SP, Brazil