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Cell fate potentials and switching kinetics uncovered in a classic bistable gen...

Fang, Xiaona; Liu, Qiong; Bohrer, Christopher; Hensel, Zach; Han, Wei; Wang, Jin; Xiao, Jie

Bistable switches are common gene regulatory motifs directing two mutually exclusive cell fates. Theoretical studies suggest that bistable switches are sufficient to encode more than two cell fates without rewiring the circuitry due to the non-equilibrium, heterogeneous cellular environment. However, such a scenario has not been experimentally observed. Here by developing a new, dual single-molecule gene-expres...

Date: 2018   |   Origin: Repositório Institucional da UNL
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