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Increased 30-Day Mortality in Very Old ICU Patients with COVID-19 Compared to P...

Guidet, B; Jung, C; Flaatten, H; Fjølner, J; Artigas, A; Bollen Pinto, B; Schefold, J; Beil, M; Sigal, S; Vernon van Heerden, P; Szczeklik, W

Purpose: The number of patients ≥ 80 years admitted into critical care is increasing. Coronavirus disease 2019 (COVID-19) added another challenge for clinical decisions for both admission and limitation of life-sustaining treatments (LLST). We aimed to compare the characteristics and mortality of very old critically ill patients with or without COVID-19 with a focus on LLST. Methods: Patients 80 years or older ...


Association of Chronic Heart Failure with Mortality in Old Intensive Care Patie...

Romano Bruno, R; Wernly, B; Wolff, G; Fjølner, J; Artigas, A; Bollen Pinto, B; Schefold, J; Kindgen‐Milles, D; Baldia, P; Kelm, M; Beil, M; Sviri, S

Aims: Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes of critically ill old (≥70 years) intensive care patients with COVID-19. Methods and results: Patients with pre-existing CHF were subclassified as having ischaemic or non-ischaemic cardiac di...


Sex-Specific Outcome Disparities in Very Old Patients Admitted to Intensive Car...

Wernly, B; Romano Bruno, R; Kelm, M; Boumendil, A; Morandi, A; Andersen, F; Artigas, A; Finazzi, S; Cecconi, M; Christensen, S; Faraldi, L

Female and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and predictors of mortality. In total, 7555 patients were included in this analysis, 3973 (53%) male and 3582 (47%) female patients. The primary endpoint was 30-day-mortality. Baseline characteristics...


Sepsis at ICU Admission Does Not Decrease 30-Day Survival in Very Old Patients:...

Ibarz, M; Boumendil, A; Haas, L; Irazabal, M; Flaatten, H; de Lange, D; Morandi, A; Andersen, F; Bertolini, G; Cecconi, M; Christensen, S; Faraldi, L

Background: The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Sepsis incidence has risen in recent years and identification of outcomes is of considerable public importance. We aimed to determine whether VIPs admitted for sepsis had different outcomes than ...


Validation of the Clinical Frailty Score (CFS) in French Language

Abraham, P; Courvoisier, DS; Annweiler, C; Lenoir, C; Millien, T; Dalmaz, F; Flaatten, H; Moreno, R; Christensen, S; de Lange, DW; Guidet, B

Background: Very old critical ill patients are a rapid expanding group. To better understand the magnitude of the challenges involved in intensive care practice for an ageing population and discuss a rational allocation of resources, healthcare practitioners need a reliable evaluation of frailty. In order to promote the adequate use of the Clinical Frailty Scale (CFS) in a wider panel of countries, we aimed to ...


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