17 documents found, page 1 of 2
Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value...
Ribeiro,Dayane C.; Russo,Helena M.; Fraige,Karina; Zeraik,Maria L.; Nogueira,Cláudio R.; Silva,Patrícia B. da; Codo,Ana C.; Calixto,Giovana M. F.Platonia insignis fruit, popularly known as bacuri, is traditionally used in folk medicine for its anti-inflammatory and antioxidant properties. Therefore, this study determined the chemical composition and biological activities of the bacuri’s shell and seeds extracts, considered residues from its consumption and industrial uses. Four biflavonoids (GB-2a, GB-1a, morelloflavone, and volkensiflavone) were identi...
METABOLÔMICA DE PLANTAS: MÉTODOS E DESAFIOS
Pilon,Alan C.; Selegato,Denise M.; Fernandes,Richard P.; Bueno,Paula C. P.; Pinho,Danielle R.; Carnevale Neto,Fausto; Freire,Rafael T.Metabolomics has played a central role in various areas of plant sciences, offering new perspectives for the advancement of agriculture, drug discovery, chemical ecology and taxonomy. Plant metabolomics (identification and quantification) aims to understand the relationship between biological systems and genetic, pathological and or environmental stimuli in terms of differential expression of the metabolism. Ow...
Chemical composition and biological properties of Ipomoea procumbens
Batiga,Saadia; Valli,Marilia; Zeraik,Maria L.; Fraige,Karina; Leme,Gabriel M.; Pitangui,Nayla S.; Almeida,Ana Marisa F.; Michel,SylvieABSTRACT Natural products have been the most valuable source of chemical compounds in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. Brazil has an exceptionally rich biodiversity, and a valuab...
Linear Peptide Analogues from Jatropha’s Orbitides Promote Migration of Human N...
Ramalho,Suelem D.; Pinto,Meri Emili F.; Andricopulo,Renata K.; Sanches,Paulo R. S.; Silveira,Edilberto R.; Cilli,Eduardo M.; Andricopulo,Adriano D.Orbitides are a class of small naturally occurring cyclic peptides with structural and functional diversities. Their chemical properties make this class feasible to be obtained by solid phase peptide synthesis (SPPS). Therefore, this synthetic accessibility enables useful application and facilitates the identification of analogues, bioactivity studies, and thus, enables them to be applied to obtain peptide libr...
Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola s...
Borges,Maiara S.; Biasetto,Carolina R.; Chapla,Vanessa M.; Ebrahimi,Samad N.; Costa,Mayra F.; Bolzani,Vanderlan S.; Araujo,Angela R.A new compound named methyl (6S,7S,2E,4E)-6,7-dihydroxy-4,6-dimethyl octanoate was isolated from Saccharicola sp. using high performance liquid chromatography-solid phase extraction-transfer tube (HPLC-SPE-TT), together with four known compounds, fusaric acid, trans-4-hydroxymellein, thymidine and adenosine. Saccharicola sp. was isolated from the stems of Eugenia jambolana Lam. (Myrtaceae) as endophytic fungus....
Griseofulvin, Diketopiperazines and Cytochalasins from Endophytic Fungi Colleto...
Chapla,Vanessa M.; Zeraik,Maria L.; Cafeu,Mariana C.; Silva,Geraldo H.; Cavalheiro,Alberto J.; Bolzani,Vanderlan S.; Young,Maria C. M.One new natural product, 1-phenylethyl-O-a-L-rhamnopyranoside, together with eight known diketopiperazines and two benzene derivatives were isolated from the endophytic fungus Colletotrichum crassipes, whereas six known compounds including two griseofulvins, three cytochalasins and one dihydroisocoumarin were produced from the endophyte Xylaria sp., both endophytic fungi are associated with leaves of Casearia s...
Cyclo-(trp-phe) diketopiperazines from the endophytic fungus Aspergillus versic...
Gubiani,Juliana R.; Teles,Helder L.; Silva,Geraldo H.; Young,Maria Cláudia M.; Pereira,José O.; Bolzani,Vanderlan S.; Araujo,Angela R.Six known compounds, three peptide derivatives: cyclo-(tryptophyl-phenylalanyl) (2), diketopiperazine dimer WIN 64821 (3) and 3-hydroxy-15H-tryptophenaline (4), one adenine derivative: 2-hydroxy-6-N-isopentenyl-adenine (5), one phtalide derivative: 4-methoxyphtalide (1) and one benzoic acid derivative: 3-hydroxy-4-(1-hydroxy-1,5-dimethyl-hexyl) benzoic acid (6), were isolated from the ethyl acetate extract of t...
Update: Biological and Chemical Aspects of Senna spectabilis
Selegato,Denise M.; Monteiro,Afif F.; Vieira,Natália C.; Cardoso,Patrícia; Pavani,Victor D.; Bolzani,Vanderlan S.; Castro-Gamboa,IanSenna spectabilis (syn Cassia spectabilis) is one of the most important species within the Fabaceae family, natively found in Central and South America, as well as parts of Asia and Africa. Due to the extensive geographical distribution, this fast-growing tree produces a wide variety of bioactive secondary metabolites, being of special interest for chemical and pharmacological studies. Phytochemical investigati...
Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor ...
Valli,Marilia; Altei,Wanessa; Santos,Ricardo N. dos; Lucca Jr.,Emilio C. de; Dessoy,Marco A.; Pioli,Renan M.; Cotinguiba,Fernando; Cachet,XavierPiperlongumine is a natural amide alkaloid isolated from several species of Piper and is described in the literature as selectively cytotoxic to several cancer cell lines. Inhibiting cell migration has gained considerable interest as an approach for discovering antimetastatic agents because this process is fundamental to metastasis. Piperlongumine, selected from cell-based assay screening of NuBBE Database, inh...
The Genus Psychotria: Phytochemistry, Chemotaxonomy, Ethnopharmacology and Biol...
Calixto,Nivea O.; Pinto,Meri Emili F.; Ramalho,Suelem D.; Burger,Marcela C. M.; Bobey,Antonio F.; Young,Maria Claudia Marx; Bolzani,Vanderlan S.Psychotria genus (Rubiaceae) is featured into the angiosperm, being the most speciose genus comprising approximately 1600 species. The available references demonstrate that Psychotria has several uses on traditional medicine including spiritual and cultural purposes, and presents great potential on pharmacological properties, especially the one related to neurodegenerative diseases. Despite its wide biological ...