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Asthma-COPD overlap: a Portuguese survey

Padrão, E.; Araújo, D.; Bom, A. Todo; Cordeiro, C. Robalo; Sousa, J. Correia de; Cardoso, J.; Morais-Almeida, M.; Costa, R.; Pavão, F.; Leite, R. B.

Introduction: The overlap between asthma and chronic obstructive pulmonary disease (COPD) (ACO) has been discussed for many years but clinical recommendations for this entity have been diverse. This study is intended to reach a consensus on diagnosis, treatment and patient orientation for ACO, within the Portuguese medical community. Methods: This study was conducted by a multidisciplinary panel of experts from...


Elevated neopterin levels in non-allergic asthma

Pinto, A. Mota; Bom, A. Todo; Pereira, S. Vale; Alves, V.; Rosa, M. Santos

Neopterin is synthesized by human monocyte-derived macrophages upon stimulation with interferon- (IFN- ). Measurement of neopterin concentration is useful to monitor cell-mediated (Th1-type) immune activation. In this study, we aimed to analyze the behaviour of neopterin in long lasting asthma considering its role as a marker of the Th1 environment and to establish the distinction between patients belonging eit...


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