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5-Fluorouracil induces enteric neuron death and glial activation during intesti...

Costa, Deiziane V. S.; Bon-Frauches, Ana C.; Silva, Angeline M. H. P.; Lima-Júnior, Roberto C. P.; Martins, Conceição S.

5-Fluorouracil (5-FU) is an anticancer agent whose main side effects include intestinal mucositis associated with intestinal motility alterations maybe due to an effect on the enteric nervous system (ENS), but the underlying mechanism remains unclear. In this report, we used an animal model to investigate the participation of the S100B/RAGE/NFκB pathway in intestinal mucositis and enteric neurotoxicity caused b...

Date: 2019   |   Origin: Oasisbr
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