4 documents found, page 1 of 1
Genotoxicity of Nicotiana tabacum leaves on Helix aspersa
Silva,Fernanda R. da; Erdtmann,Bernardo; Dalpiaz,Tiago; Nunes,Emilene; Ferraz,Alexandre; Martins,Tales L.C.; Dias,Johny F.; Rosa,Darlan P. daTobacco farmers are routinely exposed to complex mixtures of inorganic and organic chemicals present in tobacco leaves. In this study, we examined the genotoxicity of tobacco leaves in the snail Helix aspersa as a measure of the risk to human health. DNA damage was evaluated using the micronucleus test and the Comet assay and the concentration of cytochrome P450 enzymes was estimated. Two groups of snails were ...
Os efeitos da ventilação mecânica no estresse oxidativo
Mazullo Filho,João Batista Raposo; Bona,Silvia; Rosa,Darlan Pase da; Silva,Fabiano Gomes da; Forgiarini Junior,Luiz Alberto; Dias,Alexandre SimõesOBJETIVO: A ventilação mecânica constitui um dos pilares terapêuticos da unidade de terapia intensiva, entretanto, deve-se avaliar os efeitos deletérios por ela ocasionados, logo objetivamos avaliar o estresse oxidativo de pacientes internados em unidade de terapia intensiva submetidos à ventilação mecânica invasiva. MÉTODOS: Estudo transversal onde foram incluídos 12 pacientes que estavam em ventilação mecânic...
Melatonin protects the liver and erythrocytes against oxidative stress in cirrh...
Rosa,Darlan Pase da; Bona,Silvia; Simonetto,Douglas; Zettler,Claudio; Marroni,Cláudio Augusto; Marroni,Norma PossaCONTEXT: Cirrhosis is a progressive chronic hepatopathy which constitutes an irreversible stage of liver dysfunction. OBJECTIVES: To evaluate the oxidative stress in the blood of cirrhotic rats treated with the antioxidant melatonin. METHODS: Cirrhosis was induced through inhalation of carbon tetrachloride. Liver integrity was evaluated by measuring serum enzymes, oxidative damage measured by lipoperoxidation, ...
Hepatics alterations and genotoxic effects of Croton cajucara Benth (SACACA) in...
Rodrigues,Graziella; Marcolin,Éder; Bona,Silvia; Porawski,Marilene; Lehmann,Mauricio; Marroni,Norma PossaCONTEXT: Croton cajucara Benth is a plant found in Amazonia, Brazil and the bark and leaf infusions of this plant have been popularly used to treat diabetes and hepatic disorders. OBJECTIVES: This study investigated effects hepatics alterations and genotoxic and antidiabetic effect of Croton cajucara Benth bark extracts treatment in streptozotocin-induced diabetic rats. METHODS: Male Wistar rats were divided in...