2 documents found, page 1 of 1
Dengue virus capsid protein facilitates genome compaction and packaging
Boon, Priscilla L. S.; Silva Martins, Ana; Lim, Xin Ni; Enguita, Francisco J.; Santos, Nuno C.; Bond, Peter J.; Wan, Yue; Martins, Ivo C.Dengue virus (DENV) is a single-stranded (+)-sense RNA virus that infects humans and mosquitoes, posing a significant health risk in tropical and subtropical regions. Mature virions are composed of an icosahedral shell of envelope (E) and membrane (M) proteins circumscribing a lipid bilayer, which in turn contains a complex of the approximately 11 kb genomic RNA with capsid (C) proteins. Whereas the structure o...
Understanding dengue virus capsid protein disordered N‑Terminus and pep14-23-ba...
Faustino, André F.; Guerra, Gabriela M.; Huber, Roland G.; Hollmann, Axel; Domingues, Marco M.; Barbosa, Glauce M.; Enguita, Francisco J.Dengue virus (DENV) infection affects millions of people and is becoming a major global disease for which there is no specific available treatment. pep14-23 is a recently designed peptide, based on a conserved segment of DENV capsid (C) protein. It inhibits the interaction of DENV C with host intracellular lipid droplets (LDs), which is crucial for viral replication. Combining bioinformatics and biophysics, her...