2 documents found, page 1 of 1
Therapy of chronic myeloid leukemia with imatinib mesylate in Brazil: a study o...
Funke,Vaneuza A. M.; Medeiro,Carlos R.; Lima,Denise H.; Setúbal,Daniela C.; Bitencourt,Marco A.; Bonfim,Carmem M.; Ruiz,Jefferson; Zanis Neto,JoséChronic Myeloid Leukemia (CML) is a clonal disease characterized by balanced translocation between chromosomes 9 and 22 (Philadelphia chromosome). The resulting BCR-ABL gene has tyrosine kinase activity which stimulates cellular growth. Imatinib mesylate is a potent and specific inhibitor of all ABL related kinases. Ninety-eight CML patients were treated with imatinib mesylate from October 2000 to January 2003....
Reversible posterior leucoencephalopathy syndrome associated with bone marrow t...
Teive,Hélio A.G.; Brandi,Ivar V.; Camargo,Carlos H.F.; Bittencourt,Marco A.; Bonfim,Carmem M.; Friedrich,Maria L.; Medeiros,Carlos R. deReversible posterior leucoencephalopathy syndrome (RPLS) has previously been described in patients who have renal insufficiency, eclampsia, hypertensive encephalopathy and patients receiving immunosuppressive therapy. The mechanism by which immunosuppressive agents can cause this syndrome is not clear, but it is probably related with cytotoxic effects of these agents on the vascular endothelium. We report eight...