7 documents found, page 1 of 1
Propolis: a potential natural product to fight Candida species infections
Tobaldini-Valerio, Flávia; Bonfim-Mendonça, P. S.; Rosseto, H. C.; Bruschi, M. L.; Henriques, Mariana; Negri, Melyssa; Silva, Sónia CarinaAim: To evaluate the effect of propolis against Candida species planktonic cells and its counterpart's biofilms. Materials & methods: The MIC values, time-kill curves and filamentation form inhibition were determined in Candida planktonic cells. The effect of propolis on Candida biofilms was assessed through quantification of CFUs. Results: MIC values, ranging from 220 to 880 µg/ml, demonstrated higher efficien...
Propolis potential activity against Candida tropicalis adhered cells and its bi...
Tobaldini, F. K.; Bonfim-Mendonça, P. S.; Rosseto, H. C.; Bruschi, M. L.; Henriques, Mariana; Azeredo, Joana; Negri, M.; Silva, Sónia CarinaObjectives: Invasive fungal infections, such as candidiasis, represent a public health problem of major importance, and Candida tropicalis has been highlighted among the main agents of candidiasis. One of the major contributions to C. tropicalis virulence is its versatility in adapting to a variety of different habitats and the formation of surface attached microbial communities known as biofilms. Moreover, fro...
Genotypic variability and antifungal susceptibility of Candida spp. isolated fr...
Sakita, K. M.; Faria, D. R.; Tobaldini, F. K.; Bettega, E. M. S.; Negri, M.; Kioshima, E. S.; Svidzinski, T. I. E.; Bonfim-Mendonça, P. S.Objectives Candida spp. are responsible for 9095% of hematogenous fungal infections. In Brazil and Latin America, C. albicans is the most common specie, followed by C. parapsilosis and C. tropicalis. Infections caused by Candida spp. may have their origin in exogenous sources, transmitted to patients via contaminated infusions, biomedical devices or even by the hands of the hospital staff members. Molecular bio...
Assessment of in vitro biofilm formation and antifungal susceptibility of Candi...
Faria, D. R.; Sakita, K. M.; Tobaldini, F. K.; Akimoto-Gunther, L.; Negri, M.; Kioshima, E. S.; Svidzinski, T. I. E.; Bonfim-Mendonça, P. S.Objectives Vulvovaginal candidiasis (VVC) is an inflammation of the genital mucosa, which mainly affects the vulva and vagina. Candida spp. are considered commensal fungus, however, when there is imbalance in the microbiota or the host immune system is compromised, these can become pathogenic. C. albicans is responsible for most cases of VVC and is able of expressing mechanisms which allow the colonization or i...
Evaluation of propolis and its subproduct as an inhibitor of growth and biofilm...
Moraes, L. B.; Salci, T. P.; Bonfim-Mendonça, P. S.; Tobaldini, F. K.; Toledo, L. A. S.; Negri, M.; Bruschi, M. L.; Svidzinski, T. I. E.Objectives The treatment of vulvovaginal candidiasis (VVC) is still unsatisfactory, especially in pregnant women, being promising to the utilization of alternative therapies. Propolis extract solution (PES) has demonstrated antifungal efficacy and low toxicity. In addition, the subproduct of propolis extract solution (SPES) is produced during the process of preparing PES and is usually discarded, but can still ...
Virulence potential of Candida albicans isolated from oral cavity of patients w...
Godoy, J. S. R.; Ratti, B. A.; Bonfim-Mendonça, P. S.; Tobaldini, F. K.; Lautenschlager, S. O. S.; Svidzinski, T. I. E.Objective In patients with chronic renal failure (PCRF), the frequency of colonization of the oral cavity by yeasts of genus Candida spp. is high compared with healthy individuals. These yeasts have virulence factors that may contribute to the persistence of colonization and the development of these infections. The aim of this study was evaluate aspects of virulence from Candida albicans isolated from oral cavi...
Influence of Laminarin in colonisation process of Candida albicans
Bonfim-Mendonça, P. S.; Tobaldini, F. K.; Batalini, I. M.; Capoci, I. R. G.; Godoy, J. S. R.; Kioshima, E. S.; Negri, M.; Svidzinski, T. I. E.Objective Candida albicans is responsible for the majority of cases of vulvovaginal candidiasis (VVC), one of the most important candidal virulence factors is the ability to adhere to host surfaces. Chemotherapies that seek to improve the host immune response are an alterna- tive to control fungal infections. b-glucans are polymeric carbohydrates that have been reported to modulate human inflammatory responses ...