62 documents found, page 1 of 7
Nile tilapia skin (Oreochromis niloticus) for burn treatment: ultrastructural a...
Verde, Maria Elisa Quezado Lima; Ferreira Júnior, Antonio Ernando Carlos; Barros Silva, Paulo Goberlânio de; Miguel, Emilio de CastroNile tilapia (Oreochromis niloticus) skin is a well-known biomaterial used as an occlusive dressing for burn treatment. It is also an inexpensive and important source of collagen. This study aims to describe the ultrastructural aspects of Nile tilapia skin, assess its collagen amount and organization, and compare quantitative methods of histochemical and immunohistochemical analysis (in all sterilization steps ...
Tropane alkaloids from the stem bark of Erythroxylum bezerrae
Brito, Luana San de O.; Pinto, Francisco das Chagas L.; Moraes Filho, Manoel Odorico de; Rocha, Danilo D.; Mendoza, Maria Fernanda M.Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, P...
The use of Nile Tilapia skin as an occlusive biological dressing for palatal wo...
Manfredi, Gustavo Gonçalves do Prado; Cardoso, Matheus Volz; Stuani, Vitor de Toledo; Ferreira, Rafael; Zangrando, Mariana Schutzer RagghiantiRecently, the use of type I collagen obtained from Nile Tilapia (Oreochromis niloticus) was proposed for the treatment of second and third-degree burning lesions and diabetic ulcers due to its occlusive and healing properties. The aim of this report is to describe the use of Nile tilapia skin as an occlusive barrier to protect palatal wounds after the removal of free autogenous soft tissue grafts. Two patients ...
Kinase inhibition in relapsed/refractory leukemia and lymphoma settings: recent...
Machado, Caio Bezerra; Pessoa, Flávia Melo Cunha de Pinho; Silva, Emerson Lucena da; Pantoja, Laudreísa da Costa; Ribeiro, Rodrigo MonteiroCancer is still a major barrier to life expectancy increase worldwide, and hematologic neoplasms represent a relevant percentage of cancer incidence rates. Tumor dependence of continuous proliferative signals mediated through protein kinases overexpression instigated increased strategies of kinase inhibition in the oncologic practice over the last couple decades, and in this review, we focused our discussion on...
Projeto de prevenção do câncer nas escolas: educar para prevenir (Liga do Cânce...
Santos, Rafael Henrique dos; Costa, Bruno Almeida; Santos, Antonia Náyade Alves; Santos, Erika Andrade; Lopes, Gabriel GomesJá no início do século XX o eminente cirurgião inglês John Lockhart-Mummery sugeria que era para o diagnóstico precoce que deveríamos nos voltar em busca de qualquer progresso material na cura do câncer. Contudo, para efetividade desse diagnóstico precoce é fundamental que a comunidade não-médica tenha informações básicas sobre o câncer e a capacidade de reconhecer condições predisponentes para modificá-las. De...
Leu124Serfs*26, a novel AGPAT2 mutation in congenital generalized lipodystrophy...
Montenegro Junior, Renan Magalhães; Lima, Grayce Ellen da Cruz Paiva; Fernandes, Virgínia Oliveira; Montenegro, Ana Paula Dias RangelBackground: Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by the near-total loss of subcutaneous adipose tissue soon after birth, resulting in ectopic fat deposition and severe metabolic disturbances. Most cases are caused by AGPAT2 or BSCL2 gene mutations. We aimed to report two unrelated CGL patients with a novel frameshift mutation in AGPAT2 (p.Leu124Serfs*26...
Innovative treatment using tilapia skin as a xenograftfor partial thickness bur...
Lima-Junior, Edmar Maciel; Moraes Filho, Manoel Odorico de; Costa, Bruno Almeida; Fechine, Francisco Vagnaldo; Moraes, Maria Elisabete Amaral deTilapia skin has non-infectious microbiota, high amounts of type I collagen, and similar morphological structure to human skin, so it has been suggested as a potential xenograft for the management of burn wounds. A 23-year-old male patient, with no comorbidities, arrived at our burn treatment center after a thermal injury caused by contact with flames from a gunpowder explosion. Superficial partial thickness bu...
Impact of testicular sperm extraction and testicular sperm aspiration on gonada...
Barroso, Leocácio Venícius Sousa; Reges, Ricardo; Cerqueira, João Batista Gadelha; Miranda, Eduardo P.; Alcantara, Rafael Jorge Alves dePurpose: To assess the impact of sperm retrieval on the gonadal function of rats with impaired spermatogenesis by comparing testicular sperm extraction (TESE) to aspiration (TESA). The efficacy of these procedures to sperm obtainment was also compared. Materials and Methods: A pilot study showed impaired spermatogenesis, but normal testosterone (T) production after a bilateral orchidopexy applied to 26 rats, wh...
Ursodeoxycholic acid in the prevention of gallstones in patients subjected to R...
Machado, Francisco Heine Ferreira; Castro Filho, Heladio Feitosa de; Babadopulos, Rodrigo Feitosa de Albuquerque Lima; Rocha, Hermano Alexandre LimaPurpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive m...
Antifungal activity of palmatine against strains of Candida spp. resistant to a...
Campos, Rosana de Sousa; Silva, Cecília Rocha da; Andrade Neto, João Batista de; Sampaio, Letícia Serpa; Nascimento, Francisca Bruna Stefany Aires doThe incidence of fungal infections has increased and it is necessary to seek new antifungals that also act against resistant strains. Palmatine is a protoberberine alkaloid noteworthy for its various pharmacological properties, including antifungal properties. The objective of this study was to evaluate the activity of palmatine against Candida spp. strains resistant to azole in planktonic cells and biofilm, an...