2 documents found, page 1 of 1
Dissection of the pre-germinal center B-cell maturation pathway in common varia...
del Pino-Molina, Lucía; López-Granados, Eduardo; Lecrevisse, Quentin; Torres Canizales, Juan; Pérez-Andrés, Martín; Blanco, Elena; Wentink, MarjoleinIntroduction: Common Variable Immunodeficiency (CVID) is characterized by defective antibody production and hypogammaglobulinemia. Flow cytometry immunophenotyping of blood lymphocytes has become of great relevance for the diagnosis and classification of CVID, due to an impaired differentiation of mature post-germinal-center (GC) class-switched memory B-cells (MBC) and severely decreased plasmablast/plasma cell...
The EuroFlow PID orientation tube for flow cytometric diagnostic screening of p...
van der Burg, Mirjam; Kalina, Tomas; Perez-Andres, Martin; Vlkova, Marcela; Lopez-Granados, Eduardo; Blanco, Elena; Bonroy, Carolien; Sousa, Ana E.In the rapidly evolving field of primary immunodeficiencies (PID), the EuroFlow consortium decided to develop a PID orientation and screening tube that facilitates fast, standardized, and validated immunophenotypic diagnosis of lymphoid PID, and allows full exchange of data between centers. Our aim was to develop a tool that would be universal for all lymphoid PIDs and offer high sensitivity to identify a lymph...