2 documents found, page 1 of 1
N-terminal acetylation shields proteins from degradation and promotes age-depen...
Varland, Sylvia; Silva, Rui Duarte; Kjosås, Ine; Faustino, Alexandra; Bogaert, Annelies; Billmann, Maximilian; Boukhatmi, Hadi; Kellen, BarbaraMost eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal acetyltransferase and specific ubiquitin ligases. Biochemical analyses uncover that both the ubiquitin ligase complex UBR4-KCMF1 and the acetyltransferase NatC recognize p...
Decyl Gallate as a Possible Inhibitor of N-Glycosylation Process in Paracoccidi...
Alves de Paula e Silva, Ana Carolina [UNESP]; Oliveira, Haroldo Cesar de [UNESP]; Scorzoni, Liliana [UNESP]; Marcos, Caroline Maria [UNESP]Made available in DSpace on 2020-12-10T19:39:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Programa de Doutorado Sanduiche no Exterior (PDSE); Programa de Apoio ao Desenvolvimento Cientifico da...