1 document found, page 1 of 1
Sort by
Issue Date
Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial ...
Campos, Joana R.; Fernandes, Ana R.; Sousa, Raquel; Fangueiro, Joana F.; Boonme, Prapaporn; Garcia, Maria Luisa; Silva, Amelia M.; Naveros, Beatriz C.The aim of this work is development of a nontoxic, long-term stable solid lipid nanoparticles (SLN) formulation for the loading of Nimesulide (NiM) by a 22 factorial design. The optimized formulation was composed of 10wt% of glyceryl behenate and 2.5wt% of poloxamer 188. Immediately after production, Z-Ave of NiM-SLN was 166.1±0.114nm, with a polydispersity index (PI) of 0.171±0051 and zeta potential nearly neu...
Date: 2019
|
Origin: RepositóriUM - Universidade do Minho