11 documents found, page 1 of 2

Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility

Nanoparticles (NPs) assumed an important role in the area of drug delivery. Despite the number of studies including NPs are growing over the last years, their side effects on the immune system are often ignored or omitted. One of the most studied polymers in the nano based drug delivery system field is chitosan (Chit). In the scientific literature, although the physicochemical properties [molecular weight (MW) ...

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-...

Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in...

Editorial: Polymeric Nano-Biomaterials for Medical Applications: Advancements i...

Horizon 2020 framework program of the European Union, ProSafe Joint Transnational Call 2016, and from the CTI (1.1.2018 Innosuisse) under grant agreement number 19267.1 PFNM-NM.

Hazard Assessment of Polymeric Nanobiomaterials for Drug Delivery: What Can We ...

The physicochemical properties of nanobiomaterials, such as their small size and high surface area ratio, make them attractive, novel drug-carriers, with increased cellular interaction and increased permeation through several biological barriers. However, these same properties hinder any extrapolation of knowledge from the toxicity of their raw material. Though, as suggested by the Safe-by-Design (SbD) concept,...

Mucosal vaccination: opportunities and challenges

Alginate coated chitosan nanoparticles are an effective subcutaneous adjuvant f...

http://www.sciencedirect.com/science/article/B6W7N-4TFV6D6-1/2/da901d7d04c884f0b04f835c6e86c774

Immune response by nasal delivery of hepatitis B surface antigen and codelivery...

Alginate coated chitosan nanoparticles were previously developed with the aim of protecting the antigen, adsorbed on the surface of those chitosan nanoparticles, from enzymatic degradation at mucosal surfaces. In this work, this new delivery system was loaded with the recombinant hepatitis B surface antigen (HBsAg) and applied to mice by the intranasal route. Adjuvant effect of the delivery system was studied b...

Evaluation of the immune response following a short oral vaccination schedule w...

The purpose of this work was to assess the ability of recombinant hepatitis B vaccine, encapsulated in alginate-coated chitosan nanoparticles, to induce local and systemic immune responses following oral vaccination. The antigen was administered either alone or in combination with the immunopotentiator, synthetic oligodeoxynucleotide containing immunostimulatory CpG motif (CpG ODN) as adjuvant, and associated o...

Induction of lymphocytes activated marker CD69 following exposure to chitosan a...

CD69 is a very early cell activation antigen expressed on the surface of activated immune cells. It can appear within 1-2 h of activation and exhibits maximal expression levels between 18 and 24 h after stimulation. In this work, the expression profile of CD69 in mice splenocytes was evaluated following exposure to the biopolymers, chitosan or alginate and the immunostimulatory factors, CpG ODN 1826 or concanav...

Uptake studies in rat Peyer's patches, cytotoxicity and release studies of algi...

The design of particulate vaccine delivery systems, particularly for mucosal surfaces, has been a focus of interest in recent years. In this context, we have previously described the development and the characterization of a new nanosized delivery system, consisting of a model antigen adsorbed to chitosan particles and coated with sodium alginate. In the present work the ovalbumin release profiles from these co...