4 documents found, page 1 of 1
Phenotypic signatures and genetic determinants of oxacillin tolerance in a labo...
Chung, Marilyn; Borges, Vitor; Gomes, João Paulo; Lencastre, Herminia de; Tomasz, AlexanderAddition of β-lactam antibiotics to growing cultures of bacteria inhibit synthesis of the bacterial cell wall peptidoglycan accompanied by killing (loss of viable titer) and lysis (physical disintegration) of the cells. However, it has also been well established that these antibiotics are not effective in killing non-growing or slow-growing bacteria and the mechanism of this “antibiotic tolerance” is not well u...
Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
Isidro, Joana; Santos, Andrea; Nunes, Alexandra; Borges, Vitor; Silva, Catarina; Vieira, Luis; Mendes, Aristides L.; Serrano, MonicaWe describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
Genomic Study of a Clostridium difficile Multidrug Resistant Outbreak-Related C...
Isidro, Joana; Menezes, Juliana; Serrano, Monica; Borges, Vitor; Paixao, Pedro; Mimoso, Margarida; Martins, Filomena; Toscano, Cristina; Santos, Andrea
Um grande surto da Doença dos Legionários numa cidade industrial em Portugal
George, Francisco; Shivaji, Tara; Pinto, Catia Sousa; Serra, Luis Antonio Oliveira; Valente, João; Albuquerque, Maria JoãoBackground We describe the investigation and control of an outbreak of Legionnaires’ disease in Portugal in October, November and December 2014. Methods Confirmed cases were individuals with pneumonia, laboratory evidence of Legionella pneumophila serogroup 1 and exposure, by residence, occupational or leisure to the affected municipalities. 49 possible sources were reduced to four potential sources, all indust...