4 documents found, page 1 of 1
Corrigendum to Analysis of the mechanisms of action of isopentyl caffeate again...
Oliveira, Simone S. C.; Marques, Carine S. F.; Sousa, Damião P. de; Andrade, Luciana N.; Fricks, Alini T.; Jain, Sona; Branquinha, Marta H.Corrigendum to “Analysis of the mechanisms of action of isopentyl caffeate against Leishmania”. Biochimie 189 (2021) 158–167
Analysis of the mechanisms of action of isopentenyl caffeate against Leishmania
Oliveira, Simone S. C.; Marques, Carine S. F.; Sousa, Damião P. de; Andrade, Luciana N.; Fricks, Alini T.; Jain, Sona; Branquinha, Marta H.Leishmaniasis is a neglected parasitic disease for which the conventional treatment can be considered inefficient and extremely aggressive, generating several and severe side effects. Therefore, the discovery of new drug candidates is important for the improvement in the quality of life of patients. Previously, we reported the promising results of isopentyl caffeate (ICaf) against Leishmania chagasi (agent of v...
Antimycotic nail polish based on humic acid-coated silver nanoparticles for ony...
Dantas, Ketheleen N. M.; Andrade, Lucas R.; Lisboa, Erika; Santana, Victoria L.; Dos Santos, André L. S.; Mello, Thaís P.; Sangenito, Leandro S.Background: The objective of this work has been the development of silver nanoparticles (AgNPs) coated with humic acid (HA) and their incorporation into an enamel for antifungal activity. AgNPs were synthesized by chemical reduction using sodium borohydride (NaBH4) as a reducing agent and coated with HA. Uncoated AgNPs were synthesized as control. AgNPs and HAAgNPs were characterized by ultravioletvisible spect...
β-cyclodextrin/isopentyl caffeate inclusion complex: synthesis, characterizatio...
Marques, Carine S. F.; Barreto, Nathalia S.; Oliveira, Simone S. C. de; Santos, André L. S.; Branquinha, Marta H.; Sousa, Damião P. de; Castro, MayaraIsopentyl caffeate (ICaf) is a bioactive ester widely distributed in nature. Our patented work has shown promising results of this molecule against Leishmania. However, ICaf shows poor solubility, which limits its usage in clinical settings. In this work, we have proposed the development of an inclusion complex of ICaf in -cyclodextrin (-CD), with the aim to improve the drug solubility, and thus, its bioavailab...