27 documents found, page 1 of 3
Development of new phytochemical-based disinfectant formulations for the contro...
Sousa, Mariana; Borges, Anabela; Simões, ManuelBackground: Healthcare-associated infections (HAIs) remain a critical public health challenge due to the persistence of multidrug-resistant (MDR) bacteria and the inefficacy of conventional disinfectants [1]. Biofilms further enhance bacterial resistance and limit the effectiveness of biocides [2]. Phytochemicals have emerged as natural alternatives due to their antimicrobial and antibiofilm properties [3]. Thi...
Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa biofilms: a s...
Gonçalves, Ariana S. C.; Simões, Manuel; Borges, AnabelaBackground: Chronic wound infections caused by Pseudomonas aeruginosa biofilms are highly resistant to conventional treatments, necessitating innovative therapeutic strategies [1]. Antimicrobial photodynamic inactivation (aPDI) has proven to be a promising alternative [2]. However, its efficacy against Gram-negative bacteria remains suboptimal due to the restricted penetration of light and photosensitizers thro...
Targeting quorum sensing: ferulic and sinapic acids compromise Pseudomonas aeru...
Leitão, Miguel M.; Borges, Fernanda; Simões, Manuel; Borges, AnabelaBackground: Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that is frequently associated with chronic infections in immunocompromised individuals, such as those with cystic fibrosis or burns [1]. The pathogenicity and virulence of P. aeruginosa are primarily regulated by quorum sensing, with the las system playing a key role in this process. This system is essential for the formation and mainten...
Photodynamic inactivation of methicillin-resistant Staphylococcus aureus using ...
Teixeira, Lília; Fraga, Sónia; Simões, Manuel; Borges, AnabelaBackground: Antibiotic-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), pose significant challenges in the treatment of chronic wound infections. Antibacterial photodynamic therapy (aPDT) offers a localized, resistance-independent alternative to antibiotics [1]. In aPDT, bacteria are targeted by molecules called photosensitizers (PSs) that are activated by light. Natural PSs are ...
The potential of selected natural products as biofilm control agents and antibi...
Massano, Francisca; Sousa, Mariana; Borges, Anabela; Simões, ManuelBackground: The emergence of multidrug-resistant bacteria, especially within biofilms, poses a serious public health threat and represents a major challenge for effective infection management. Traditional antibiotics often fail to effectively treat bacteria and biofilm-associated infections, prompting the need for novel strategies to combat bacterial resistance and biofilm formation. Natural compounds, such as ...
Bidimensional extensions of balancing and Lucas-balancing numbers
Chimpanzo, J.; Catarino, Paula; Vasco, Paulo; Borges, AnabelaIn this article bidimensional extensions of balancing and Lucas-balancing numbers are introduced, as well as some properties of these new bidimensional sequences.
Correction: Correia et al. Beyond Penicillin: The Potential of Filamentous Fung...
Correia, João; Borges, Anabela; Simões, Manuel; Simões, Lúcia ChavesManuel Simões was included as a corresponding author in the original publication [1] by mistake. The corrected corresponding author should be Lúcia C. Simões, and the email is updated accordingly. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.
Exploring the potential of combined natural photosensitizers, gentamycin, and c...
Gonçalves, Ariana S. C.; Simões, Manuel; Borges, AnabelaBackground: The increasing prevalence of wound infections poses a growing threat to the healthcare system [1]. Compounding this challenge, the presence of biofilms significantly impairs both the healing process and the effectiveness of the treatment of wound infections [2]. Antimicrobial photodynamic inactivation (aPDI) has shown promising results in combating this global problem. However, its potential agains...
Efficacy of selected phenolic acids in inhibiting the LasI/LasR and PQS quorum ...
Leitão, Miguel M.; Borges, Fernanda; Simões, Manuel; Borges, AnabelaBackground: Quorum sensing (QS) is a bacterial intercellular communication mechanism mediated by extracellular signalling molecules known as autoinducers [1]. LasI/LasR and pseudomonas quinolone signalling (PQS) are fundamental components of the QS system in Pseudomonas aeruginosa. These systems perform a crucial role in the regulation of gene expression in response to cell density, coordination of bi...
Development of a hydrogel with antioxidant and antibacterial properties loaded ...
S. Teixeira, Lília; Sousa, Mariana; Massano, Francisca; Simões, Manuel; Borges, AnabelaBackground: Chronic wound infections are an emerging issue affecting millions of people globally, with profound psychological and socio-economic consequences [1]. Nonetheless, effective treatments to promote wound healing remain scarce [2]. Natural hydrogels appear as promising alternative wound dressings due to exudate absorption capacity and inherent wound-healing properties [3]. Objective: This study explore...