6 documents found, page 1 of 1
O papel do RNA longo não codificante H19 no desenvolvimento da síndrome mielodi...
Borges, Daniela de PaulaH19 is a long noncoding RNA (lncRNA) expressed only from the maternal allele by imprinting. H19 transcription is controlled by the Imprinting Control Region (ICR) of the Differentially Methylated Region (DMR) H19DMR mediated by the protein CTCF. H19 regulates several physiological functions and can act both as an oncogene and tumor suppressor in many neoplasias, suggesting a promising target for therapies, espe...
Interleukin-8 and nuclear factor kappa B are increased and positively correlate...
Matos, Anacélia Gomes de; Ribeiro Junior, Howard Lopes; Borges, Daniela de Paula; Okubo, Bruno Memória; Sousa, Juliana Cordeiro deThe pathogenesis of myelodysplastic syndromes (MDS) is complex and depends on the interaction between aberrant hematopoietic cells and their microenvironment, probably including aberrations in cytokines and their signaling pathways. To evaluate interleukin-8 (IL-8) plasma levels and nuclear factor kappa B (NF-kB) in patients with MDS and to test possible correlation between IL-8 and NFKb, a total of 45 individu...
Myelodysplastic syndrome patients present more severe respiratory muscle impair...
Okubo, Bruno Memória; Matos, Anacélia Gomes de; Ribeiro Junior, Howard Lopes; Borges, Daniela de Paula; Oliveira, Roberta Taiane Germano deThe ageing process is associated with gradual decline in respiratory system performance. Anemia is highly prevalent among older adults and usually associated with adverse outcomes. Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic malignancies with increasing incidence with age and characterized by anemia and other cytopenias. The main objectives of this study were to evaluate respiratory...
New polymorphisms of Xeroderma Pigmentosum DNA repair genes in myelodysplastic ...
Santiago, Sabrina Pinheiro; Ribeiro Junior, Howard Lopes; Sousa, Juliana Cordeiro de; Borges, Daniela de Paula; Oliveira, Roberta Taiane Germano deThe association between Xeroderma Pigmentosum DNA repair genes ( XPA rs1800975, XPC rs2228000, XPD rs1799793 and XPF rs1800067) polymorphisms and myelodysplastic syndrome (MDS) have not been reported. To assess the functional role between these polymorphisms and MDS, we evaluated 189 sam- ples stratified in two groups: 95 bone marrow samples from MDS patients and 94 from healthy elderly volunteers used as contr...
DNA repair gene expressions are related to bone marrow cellularity in myelodysp...
Ribeiro Jr., Howard L.; Maia, Allan Rodrigo S.; Oliveira, Roberta Taiane G. de; Costa, Marília Braga; Farias, Izabelle Rocha; Borges, Daniela de PaulaObjective To evaluate the expression of genes related to nuclear excision (ERCC8, XPA and XPC), homologous recombination and non-homologous end-joining (ATM, BRCA1, BRCA2 and LIG4) repair mechanisms, using quantitative PCR methodologies, and it relation with bone marrow cellularity in myelodysplastic syndrome (MDS). Methods and results A total of 51 adult de novo patients with MDS (3 refractory anaemia (RA), 11...
Estudo de alvos moleculares relacionados à mitose e ao ciclo celular em pacient...
Borges, Daniela de PaulaMyelodysplastic syndrome (MDS) are a heterogeneous group of clonal disease characterized by insufficiency of bone marrow, increase of apoptosis and increased risk of acute myeloid leukemia (AML) progression. Proteins related to the mitotic spindle (AURKA, AURKB, TPX2), to the mitotic checkpoint (MAD2, CDC20) and the regulation of the cell cycle (CDKN1A) are directly related to chromosome stability and tumor dev...