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Knockout of insulin-degrading enzyme leads to mice testicular morphological cha...

Meneses, Maria João; Borges, Diego O.; Dias, Tânia R.; Martins, Fátima O.; Oliveira, Pedro F.; Macedo, M. Paula; Alves, Marco G.

Insulin-degrading enzyme (IDE) is a zinc metalloprotease responsible for degrading and inactivating several bioactive peptides, including insulin. Individuals without this enzyme or with a loss-of-function mutation in the gene that codifies it, present hyperinsulinemia. In addition, impairment of IDE-mediated insulin clearance is associated with the development of metabolic diseases, namely prediabetes. Althoug...

Date: 2019   |   Origin: RIA - Repositório Institucional da Universidade de Aveiro
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