46 documents found, page 1 of 5

3-Hydroxypyridin-4-one based derivatives as promising neuroprotective agents fo...

Background: Parkinson’s Disease (PD) is a multifactorial, complex and progressive neurodegenerative disease, characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta [1,2]. Several pathophysiological mechanisms are involved in PD, namely Lewy bodies formation, mitochondrial dysfunction, neuroinflammation, oxidative stress and iron accumulation within the brain [3]. Iron tr...

Mechanisms behind the neurotoxicity of 2C-I and 25I-NBOMe drugs

Background: New Psychoactive Substances (NPS) pose significant health and legal risks worldwide. At the end of 2021, the European Monitoring Centre for Drugs and Drug Addiction was monitoring 886 NPS, 106 of them phenethylamines [1]. Phenethylamine derivatives include 2,5-dimethoxyphenethylamine-based (2C) and N-benzylphenethylamine-based (NBOMe) drugs, widely known for their psychedelic effects. However, their...

The determinants of risk reporting during the period of adoption of Basel II Ac...

The purpose of this paper to analyze the risk reporting practices and its determinants of commercial banks during the period of the adoption of the Basel II Accord in Portugal. The paper conducts a content analysis of the risk and risk management sections included in the management reports and the notes of the annual reports of Portuguese commercial banks, for the years 2007, 2010 and 2013. Findings show that t...

Surface wiping test to study biocide-cinnamaldehyde combination to improve effi...

Drug biophysical profiling using lipid-based colloidal nanosystems and human se...

[Excerpt] Why? In the drug discovery process it should be considered that in physiological environment there will be reciprocal interactions between drugs and biological interfaces, such as cell membranes or plasma proteins, and from those interactions different pharmacokinetic profiles can be achieved.[...]

Drug biophysical profiling using lipid-based colloidal nanosystems and human se...

The development of new drugs is a highly complex and expensive process, so it is crucial that less promising compounds are rejected early in the discovery phase before progressing to more expensive phases. This scenario impels researchers to refine and speed up the drug discovery process and to seek tools to support decisions related to modifications of the drug chemical structure to improve drugs’ properties a...

Smart cities, smart tourism? The case of the city of Porto

The so-called Smart Cities have been playing an important role in the academic literature as well as in the agenda of public policies. With the forward thinking of “creating” new urban development models, the cities intend to strategically positioning themselves and at the same time develop cooperation networks. Frequently using the Information and Communication Technologies (while as a means to an end and not ...

Impression management and self-presentation dissimulation in Portuguese chairma...

Drawn on social psychology theory of impression management, the present study tries to assess the way Portuguese managers build their narratives in Chairman’s Statement to manage stakeholders’ perceptions on corporate image, in a period of time of scarce resources. The paper’s theoretical framework draws on elements of social psychology theory of impression management developed by Leary and Kowalski (1990). Thr...

Carbon nanotube β-cyclodextrin-modified electrode for quantification of cocaine...

Detection and quantification of cocaine is a key tool in fields such as police apprehensions and the fight against drug trafficking. Thus, a simple, fast and inexpensive electroanalytical methodology for the determination of cocaine in seized street samples has been developed, employing linear sweep voltammetry. The method is based on the use of a glassy carbon (GC) electrode modified by a combination of multi-...

Electrochemical sensor for simultaneous determination of herbicide MCPA and its...

The development and application of a polyaniline/carbon nanotube (CNT) cyclodextrin matrix (PANI-β-CD/MWCNT)-based electrochemical sensor for the quantitative determination of the herbicide 4-chloro-2-methylphenoxyacetic acid (MCPA) and its main transformation product 4-chloro-2-methylphenol in natural waters are described. A simple cyclic voltammetry-based electrochemical methodology, in phosphate buffer solut...