96 documents found, page 1 of 10
Targeting quorum sensing: ferulic and sinapic acids compromise Pseudomonas aeru...
Leitão, Miguel M.; Borges, Fernanda; Simões, Manuel; Borges, AnabelaBackground: Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that is frequently associated with chronic infections in immunocompromised individuals, such as those with cystic fibrosis or burns [1]. The pathogenicity and virulence of P. aeruginosa are primarily regulated by quorum sensing, with the las system playing a key role in this process. This system is essential for the formation and mainten...
Novel Edaravone Derivatives as Neuroprotective Agents for the Treatment of ALS
Barreiro, Sandra; Cagide, Fernando; Borges, Fernanda; Remião, Fernando; Silva, RenataBackground: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease (ND) with limited treatment options [1]. Although with some drawbacks, Edaravone is one of the available drugs for ALS that targets oxidative stress (OS), a key factor in the pathophysiology of this disease [1]. Objective: This work aimed to evaluate the cytotoxic effects and neuroprotective potential of a new series of Edaravone der...
Bonding to Psychedelics: Synthesis of Molecularly Imprinted Polymers Targeting ...
Martins, Daniel; Fernandes, Carlos; Mendes, Ricardo F.; Cagide, Fernando; Silva, António Fernando; Borges, Fernanda; Garrido, Jorge; Garrido, JorgeThe increasing interest in utilizing psychedelics for therapeutic purposes demands the development of tools capable of efficiently monitoring and accurately identifying these substances, thereby supporting medical interventions. 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) has gained significant popularity as one of the most widely used psychedelic compounds in non-medical settings. In this study, we aimed to cre...
Microencapsulation of the Biocide Benzisothiazolinone (BIT) by Inclusion in Met...
Silva, Vânia F. M.; Silva, Aurora; Garrido, Ermelinda M. P. J.; Borges, Fernanda; Gaspar, Alexandra; Garrido, Jorge P. M. J.; Garrido, E. ManuelaThe excessive use of biocides has considerable environmental and economic impacts; this is why new technologies have been sought to decrease the concentration levels applied in an effort to reduce the use of these substances. Microencapsulation using cyclodextrins has been widely used in the food and pharmaceutical industries as a way of reducing the concentrations of the active substance necessary to achieve a...
Biological and Medicinal Properties of Natural Chromones and Chromanones
Gaspar, Alexandra; Garrido, E. Manuela P. J.; Borges, Fernanda; Garrido, Jorge M. P. J.Emerging threats to human health require a concerted effort to search for new treatment therapies. One of the biggest challenges is finding medicines with few or no side effects. Natural products have historically contributed to major advances in the field of pharmacotherapy, as they offer special characteristics compared to conventional synthetic molecules. Interest in natural products is being revitalized, in...
Efficacy of selected phenolic acids in inhibiting the LasI/LasR and PQS quorum ...
Leitão, Miguel M.; Borges, Fernanda; Simões, Manuel; Borges, AnabelaBackground: Quorum sensing (QS) is a bacterial intercellular communication mechanism mediated by extracellular signalling molecules known as autoinducers [1]. LasI/LasR and pseudomonas quinolone signalling (PQS) are fundamental components of the QS system in Pseudomonas aeruginosa. These systems perform a crucial role in the regulation of gene expression in response to cell density, coordination of bi...
Rivastigmine-Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Co...
Vicente-Zurdo, David; Brunetti, Leonardo; Piemontese, Luca; Guedes, Beatriz; Cardoso, Sandra M.; Chavarria, Daniel; Borges, Fernanda; Madrid, YolandaWith the goal of combating the multi-faceted Alzheimer's disease (AD), a series of Rivastigmine-Benzimidazole (RIV-BIM) hybrids was recently reported by us as multitarget-directed ligands, thanks to their capacity to tackle important hallmarks of AD. In particular, they exhibited antioxidant activity, acted as cholinesterase inhibitors, and inhibited amyloid-β (Aβ) aggregation. Herein, we moved forward in this ...
From Non-Alcoholic Fatty Liver to Hepatocellular Carcinoma: A Story of (Mal)Ada...
Amorim, Ricardo; Magalhães, Carina C.; Borges, Fernanda; Oliveira, Paulo J.; Teixeira, JoséNon-alcoholic fatty liver disease (NAFLD) is a global pandemic affecting 25% of the world's population and is a serious health and economic concern worldwide. NAFLD is mainly the result of unhealthy dietary habits combined with sedentary lifestyle, although some genetic contributions to NAFLD have been documented. NAFLD is characterized by the excessive accumulation of triglycerides (TGs) in hepatocytes and enc...
Effect of a Novel Hydroxybenzoic Acid Based Mitochondria Directed Antioxidant M...
Santos, João Campos; Marques, Carla Cruz; Baptista, Maria Conceição; Pimenta, Jorge; Teixeira, José; Montezinho, Liliana; Cagide, FernandoSperm cells are particularly vulnerable to reactive oxygen species (ROS), impairing their fertilizing ability. Our objective was to study the effect of a novel mitochondrial-directed antioxidant, AntiOxBEN2, on bovine sperm function. This antioxidant was added to the semen capacitation medium (CAP), during the swim-up process, and to the fertilization medium (FERT) during the co-incubation of matured oocytes an...
Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Weste...
Amorim, Ricardo; Simões, Inês C. M.; Teixeira, José; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; Tavares, Ludgero C.Non-alcoholic fatty liver disease (NAFLD) is a health concern affecting 24% of the population worldwide. Although the pathophysiologic mechanisms underlying disease are not fully clarified, mitochondrial dysfunction and oxidative stress are key players in disease progression. Consequently, efforts to develop more efficient pharmacologic strategies targeting mitochondria for NAFLD prevention/treatment are underw...