99 documents found, page 1 of 10
Hydroxycinnamic and Hydroxybenzoic-Based Mitochondriotropic Antioxidants Improv...
Ferreira, Filipa; Lourenço, Beatriz; Teixeira, José; Cagide, Fernando; Benfeito, Sofia; Lidon, Fernando; Borges, Fernanda; Oliveira, Paulo J.Assisted reproductive technologies (ART) use has increased over the past decades. However, reports concerning ART’s low efficiency continue to emerge, citing causes related to lower embryo quality and pregnancy rates compared to their in vivo counterparts. One of the setbacks of ART is oxidative stress, which can impair embryo developmental rates. Mitochondrial redox and energetic homeostasis determine both cel...
Targeting quorum sensing: ferulic and sinapic acids compromise Pseudomonas aeru...
Leitão, Miguel M.; Borges, Fernanda; Simões, Manuel; Borges, AnabelaBackground: Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that is frequently associated with chronic infections in immunocompromised individuals, such as those with cystic fibrosis or burns [1]. The pathogenicity and virulence of P. aeruginosa are primarily regulated by quorum sensing, with the las system playing a key role in this process. This system is essential for the formation and mainten...
Novel Edaravone Derivatives as Neuroprotective Agents for the Treatment of ALS
Barreiro, Sandra; Cagide, Fernando; Borges, Fernanda; Remião, Fernando; Silva, RenataBackground: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease (ND) with limited treatment options [1]. Although with some drawbacks, Edaravone is one of the available drugs for ALS that targets oxidative stress (OS), a key factor in the pathophysiology of this disease [1]. Objective: This work aimed to evaluate the cytotoxic effects and neuroprotective potential of a new series of Edaravone der...
Two cinnamic acid derivatives as inhibitors of Pseudomonas aeruginosa las and p...
Leitão, Miguel M.; Gonçalves, Ariana S.C.; Sousa, Sérgio F; Borges, Fernanda; Simões, Manuel; Borges, AnabelaIntroduction: Quorum sensing (QS) is a bacterial communication mechanism that regulates gene expression, playing a crucial role in various physiological processes. Interfering with this signalling pathway is a promising strategy to control bacterial pathogenicity and virulence. Objectives: This study evaluated the potential of two cinnamic acid derivatives, ferulic and sinapic acids, to inhibit the las and pqs ...
Assisted Reproduction Technologies (ART)
Ferreira, Filipa C.; Teixeira, José; Lidon, Fernando; Cagide, Fernando; Borges, Fernanda; Pereira, Rosa M.L.N.In the last decades, major changes in ecosystems related to industrial development and environmental modifications have had a direct impact on mammalian fertility, as well as on biodiversity. It is widely demonstrated that all these changes impair reproductive function. Several studies have connected the increase of reactive oxygen species (ROS) generated in mitochondria to the recently identified decline of fe...
Efficacy of selected phenolic acids in inhibiting the LasI/LasR and PQS quorum ...
Leitão, Miguel M.; Borges, Fernanda; Simões, Manuel; Borges, AnabelaBackground: Quorum sensing (QS) is a bacterial intercellular communication mechanism mediated by extracellular signalling molecules known as autoinducers [1]. LasI/LasR and pseudomonas quinolone signalling (PQS) are fundamental components of the QS system in Pseudomonas aeruginosa. These systems perform a crucial role in the regulation of gene expression in response to cell density, coordination of bi...
Microencapsulation of the Biocide Benzisothiazolinone (BIT) by Inclusion in Met...
Silva, Vânia F. M.; Silva, Aurora; Garrido, Ermelinda M. P. J.; Borges, Fernanda; Gaspar, Alexandra; Garrido, Jorge P. M. J.; Garrido, E. ManuelaThe excessive use of biocides has considerable environmental and economic impacts; this is why new technologies have been sought to decrease the concentration levels applied in an effort to reduce the use of these substances. Microencapsulation using cyclodextrins has been widely used in the food and pharmaceutical industries as a way of reducing the concentrations of the active substance necessary to achieve a...
Bonding to Psychedelics: Synthesis of Molecularly Imprinted Polymers Targeting ...
Martins, Daniel; Fernandes, Carlos; Mendes, Ricardo F.; Cagide, Fernando; Silva, António Fernando; Borges, Fernanda; Garrido, Jorge; Garrido, JorgeThe increasing interest in utilizing psychedelics for therapeutic purposes demands the development of tools capable of efficiently monitoring and accurately identifying these substances, thereby supporting medical interventions. 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) has gained significant popularity as one of the most widely used psychedelic compounds in non-medical settings. In this study, we aimed to cre...
Biological and Medicinal Properties of Natural Chromones and Chromanones
Gaspar, Alexandra; Garrido, E. Manuela P. J.; Borges, Fernanda; Garrido, Jorge M. P. J.Emerging threats to human health require a concerted effort to search for new treatment therapies. One of the biggest challenges is finding medicines with few or no side effects. Natural products have historically contributed to major advances in the field of pharmacotherapy, as they offer special characteristics compared to conventional synthetic molecules. Interest in natural products is being revitalized, in...
Rivastigmine-Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Co...
Vicente-Zurdo, David; Brunetti, Leonardo; Piemontese, Luca; Guedes, Beatriz; Cardoso, Sandra M.; Chavarria, Daniel; Borges, Fernanda; Madrid, YolandaWith the goal of combating the multi-faceted Alzheimer's disease (AD), a series of Rivastigmine-Benzimidazole (RIV-BIM) hybrids was recently reported by us as multitarget-directed ligands, thanks to their capacity to tackle important hallmarks of AD. In particular, they exhibited antioxidant activity, acted as cholinesterase inhibitors, and inhibited amyloid-β (Aβ) aggregation. Herein, we moved forward in this ...