23 documents found, page 1 of 3
The impact on productivity costs of reducing unemployment in patients with adva...
Vasconcelos de Matos, L; Borges, M; Oliveira, AT; Bulhosa, C; Miguel, LS; Fidalgo de Freitas, T; Cunha, R; Mendes, AD; Arede, AJ; Marques, C; Costa, DAThis study aimed to characterize the employment status and work-related conditions of patients with advanced breast cancer (ABC) in Portugal and quantify the productivity costs of premature abandonment of the work market while evaluating strategies to promote employment. The analysis was based on a cumulative incidence model for estimation of ABC prevalence and on a cross-sectional study characterizing the empl...
A Cross‐Sectional Assessment of Frailty, Falls and Perceptions of Ageing in Peo...
Levett, TJ; Vera, JH; Jones, CI; Bremner, S; Leon, A; Begovac, J; Apers, L; Borges, M; Zekan, S; Teofilo, E; Garcia, F; Whetham, JObjective: To evaluate frailty, falls and perceptions of ageing among clinically stable individuals with HIV, engaged with remote healthcare delivered via a novel smartphone application. Methods: This was a multi-centre European cross-sectional, questionnaire-based sub-study of EmERGE participants. Frailty was assessed using the five-item FRAIL scale. Present criteria were summed and categorized as follows: 0, ...
The Efficiency of the EmERGE Platform for Medically Stable People Living with H...
Beck, E; Mandalia, S; Yfantopoulos, P; Jones, C; Bremner, S; Whetham, J; Cunha, AS; Teofilo, E; Rodrigues, G; Borges, MBackground: The aim of this study was to calculate the cost-effectiveness of the EmERGE Pathway of Care for medically stable people living with HIV in the Hospital Capuchos, Centro Hospitalar Universitário de Lisboa Central (HC-CHLC). The app enables individuals to receive HIV treatment information and communicate with caregivers. Methods: This before-and-after study collected the use of services data 1 year be...
Tuberculose em Idade Pediátrica: Experiência de 12 Anos num Centro Terciário de...
Borges, M; Rocha, AP; Veiga de Macedo, C; Milheiro Silva, T; Gouveia, C; Candeias, F; Brito, MJIntroduction: The diagnosis of tuberculosis in children is a challenge namely because extrapulmonary tuberculosis and severe disease are more frequent in this age group. The aim of this study was to evaluate and reflect about severe tuberculosis in pediatric age, in a metropolitan area of Lisbon. Material and methods: Descriptive study about patients under 18 years of age admitted with tuberculosis disease in a...
Atherosclerosis in the Primary Health Care Setting: A Real-Word Data Study
Ascenção, R; Alarcão, J; Araújo, F; Costa, J; Fiorentino, F; Gil, V; Gouveia, M; Lourenço, F; Mello e Silva, A; Vaz Carneiro, A; Borges, MIntroduction and objectives: To characterize patients with atherosclerosis, a disease with a high socioeconomic impact, in the Lisbon and Tagus Valley Health Region. Methods: A cross-sectional observational study was carried out through the Lisbon and Tagus Valley Regional Health Administration primary health care database, extracting data on the clinical and demographic characteristics and resource use of adul...
IFNγ and iNOS-Mediated Alterations in the Bone Marrow and Thymus and Its Impact...
Barreira-Silva, P; Melo-Miranda, R; Nobrega, C; Roque, S; Serre-Miranda, C; Borges, M; Armada, G; Calçada, DS; Behar, SM; Appelberg, R; Correia-Neves, MDisseminated infection with the high virulence strain of Mycobacterium avium 25291 leads to progressive thymic atrophy. We previously showed that M. avium-induced thymic atrophy results from increased glucocorticoid levels that synergize with nitric oxide (NO) produced by interferon gamma (IFNg) activated macrophages. Where and how these mediators act is not understood.We hypothesized that IFNg and NO promote t...
Comparing the cost of non-metastatic breast cancer care in a low-income vs a hi...
Brandão, M; Morais, S; Guisseve, A; Bata, G; Borges, M; Tulsidás, S; Pereira, S; Carrilho, C; Lunet, NBreast cancer incidence is rising in low-income countries, but there is limited information regarding health resource allocation for its care. We assessed the cost of care during the first three years after diagnosis in a low-income country (Mozambique; n = 162 women) and compared it with a high-income country (Portugal, n = 703 women). Local currency prices were converted to 2019 international dollars (Int$). ...
Vaccines in Congenital Toxoplasmosis: Advances and Perspectives
Barros, M; Teixeira, D; Vilanova, M; Correia, A; Teixeira, N; Borges, MCongenital toxoplasmosis has a high impact on human disease worldwide, inducing serious consequences from fetus to adulthood. Despite this, there are currently no human vaccines available to prevent this infection. Most vaccination studies against Toxoplasma gondii infection used animal models in which the infection was established by exogenous inoculation. Here, we review recent research on potential T. gondii...
The burden of atherosclerosis in Portugal
Costa, J; Alarcão, J; Araujo, F; Ascenção, R; Caldeira, D; Fiorentino, F; Gil, V; Gouveia, M; Lourenço, F; Mello E Silva, A; Sampaio, F; Vaz-Carneiro, AAims: This paper sought to estimate the burden of disease attributable to atherosclerosis in mainland Portugal in 2016. Methods and results: The burden of atherosclerosis was measured in disability-adjusted life years (DALY) following the latest 2010 Global Burden of Disease (GBD) methodology. DALYs were estimated as the sum of years of life lost (YLL) with years lived with disability (YLD). The following clini...
Toxoplasma gondii infection reduces serum progesterone levels and adverse effec...
Brito, C; M, Silva, T; M Castro, M; Wyrwas, W; Oliveira, B; M, Fonseca, B; Oliveira, P; W, Roberts, C; Teixeira, N; Borges, MAims: Pregnant BALB/c mice infected with a Toxoplasma gondii type II strain were used to determine how pregnancy interferes with the development of maternal immunity to T gondii and how infection disrupts pregnancy and foetal development. Methods: Maternal and foetal parasite loads were assessed by amplification of T gondii SAG1 using qPCR. Adverse effects of infection were evaluated on foetal-placental develop...