8 documents found, page 1 of 1
Art & Biochemistry - Bioquímica e Sociedade: a bioquímica dedicada à arte e ao ...
Caldeira, A. T.; Martins, M. R.; Salvador, Cátia; Arantes, S.; Bhattacharya, S.; Palma, V.; Silva, I.Established in 2009, the HERCULES Lab is a research infrastructure from the University of Évora, devoted to the study and valorisation of cultural heritage, focusing on the integration of physical and material sciences methodologies and tools in interdisciplinary approaches. Nowadays, the laboratory researchers are engaged in the material and historical study of different cultural heritage artifacts, namely, ar...
Biodegradation of pesticides by adapted fungi. Potential use on biopurification...
Pinto, A. P.; Teixeira, D. M.; Caldeira, A. T.Biopurification systems (BPSs) constitute a valuable approach to mitigate/reduce the contamination of water sources with pesticides. These systems employ the degrading capacity of a biomixture to avoid/minimize, in a simple and low cost way, the pollution of discharging of pesticide-containing wastewater in the aquatic environment. Therefore processes and parameters controlling depuration ability of BPSs should...
Gaining insight into the photophysical properties of a coumarin STP ester with ...
González-Pérez, M.; Ooi, S. Y.; Martins, S.; Prates Ramalho, João P.; Pereira, A.; Caldeira, A. T.Coumarins have a long history as fluorescent dyes.1 These benzopyrones are widely distributed in nature and new ones are continuously being synthesized and commercialized due to their excellent light stability and the relative ease in tuning their photophysical properties by chemical substitution.2–4 Coumarins that favor reactions of interest with target biomolecules, metals or reactive groups have been extensi...
Uma rapida ferramenta analítica para a deteção e análise da colonização microbi...
Pérez, Marina González; Vieira, Ricardo; Pereira, António; Candeias, António; Caldeira, A. T.Neste trabalho desenvolveu-se um protocolo que permite a aplicação da técnica FISH para avaliar as comunidades microbianas presentes em argamassas de forma invasiva ou não-invasiva, ex situ ou in situ. Os ensaios foram efetuados em provetes de argamassas inoculadas artificialmente com microrganismos da coleção HERCULES-Biotec Lab, Universidade de Évora. Utilizaram-se duas sondas oligonucleotídicas EUK516-Cy3 e ...
THE ROLE OF CHOLINESTERASES IN ALZHEIMER’S DISEASE: SCREENING OF TARGET COMPOUNDS
Bacalhau, P.; San Juan, A.; Marques, C.; Peixoto, D.; Burke, A.; Caldeira, A. T.; Martins, M. R.Background: Alzheimer's disease (AD) is the most common form of dementia and causes a progressive and irreversible neurodegeneration. The loss of cholinergic neurons leads to the progressive reduction of acetylcholine (ACh) in the brain and resulting cognitive impairment in AD. ACh is hydrolyzed by both acetylcholinesterase (AChE) and butirylcholinesterase (BuChE). It was found that in the course of the disease...
O-coumaric acid ester, a potential early signaling molecule in Pinus pinea and ...
Ragonezi, C.; Teixeira, D.; Caldeira, A. T.; Martins, M .R.; Santos-Silva, C.; Ganhão, E.; Klimaszewska, K.; Zavattieri, M. A.During ectomycorrhizal (ECM) establishment, biochemical signals lead to the development of complex structures in both the plant and the fungus that ultimately result in the formation of an ectomycorrhiza. The cross-talk between partners begins before physical contact. Our objective was to investigate the chemical nature of the signals during the first stages of in vitro mycorrhization of Pinus pinea with Pisoli...
Avaliação da Actividade Microbiana de Bisfosfonatos Derivados do Indazole
Teixeira, A. P. S.; Fialho, A. M; Martins, M. R.; Matias, G.; Arantes, S.; Teixeira, F. C.; Caldeira, A. T.Os bisfosfonatos (BPs) são um grupo de compostos derivados do ácido bisfosfónico e dos seus sais. Os bisfosfonatos (BPs) são uma classe importante de fármacos com um largo espectro de aplicações no tratamento de doenças do metabolismo mineral do osso, como a osteoporose, a doença de Paget e metástases ósseas, com uma acção inibidora sobre os osteoclastos, promovendo uma diminuição da reabsorção óssea. Recenteme...
Bisfosfonatos derivados do indazole: síntese e avaliação da actividade biológica
Matias, G.; Teixeira, Fatima; Martins, M. R.; Caldeira, A. T.; Teixeira, António P. S.