2 documents found, page 1 of 1
Synthesis of Nerol Derivatives Containing a 1,2,3-Triazole Moiety and Evaluatio...
Teixeira,Róbson R.; Silva,Adalberto M. da; Siqueira,Raoni P.; Gonçalves,Victor Hugo S.; Pereira,Higor S.; Ferreira,Rafaela S.; Costa,Adilson V.In the present investigation, a collection of twenty two nerol derivatives, containing 1,2,3-triazolic appendages, was synthesized and screened in vitro for their cytotoxic activity against HL60, Nalm6, and Jurkat human leukemia cells as well as against B16F10 (melanoma cell line). In most cases, derivatives were able to reduce cell viability. The most potent compound (Z)-4-(((3,7-dimethylocta-2,6-dien-1-yl)oxy...
In vitro trypanocidal evaluation of pinane derivatives from essential oils of r...
Sartorelli,Patricia; Santana,Jefferson S.; Guadagnin,Rafael C.; Lago,João Henrique G.; Pinto,Érika G.; Tempone,André G.; Stefani,Hélio A.Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pi...