4 documents found, page 1 of 1
Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blo...
Silva, Camila Meirelles S.; Wanderley, Carlos Wagner S.; Veras, Flavio P.; Sonego, Fabiane; Nascimento, Daniele C.; Gonçalves, Augusto V.Made available in DSpace on 2022-04-29T08:46:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-23; Multiple organ dysfunction is the most severe outcome of sepsis progression and is highly correlated with a worse prognosis. Excessive neutrophil extracellular traps (NETs) are critical players in the development of organ failure during sepsis. Therefore, interventions targeting NET release would likely...
Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis
Colón, David F.; Wanderley, Carlos W.; Franchin, Marcelo; Silva, Camila M.; Hiroki, Carlos H.; Castanheira, Fernanda V. S.; Donate, Paula B.Background: Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown. Methods: Infant (2 weeks old) and adult (6 weeks old) mice were submitted to sepsis by intraperitoneal (i.p.) injection of bacteria suspension or lipopolysaccharide (LPS). Neutrophil infiltration, bacteremia, ...
Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice P...
Santos, Nilton B Dos; Franco, Roseane D.; Camarini, Rosana; Munhoz, Carolina D.; Eichler, Rosangela A S; Gewehr, Mayara C F; Reckziegel, PatriciaMade available in DSpace on 2019-10-06T16:50:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-19; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C5...
The adaptor protein myd88 is a key signaling molecule in the pathogenesis of ir...
Wong, Deysi V. T.; Lima-Júnior, Roberto C. P.; Carvalho, Cibele B. M.; Borges, Vanessa F.; Wanderley, Carlos W. S.; Bem, Amanda X. C.Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL–1 and IL–18. These molecules and toll-like receptors (TLRs) activate a common signaling pathway that involves the Myeloid Differentiation adaptor protein, MyD88, whose role in intestinal mucositis is unknown. Then, we evalu...