2 documents found, page 1 of 1
Neuroprotective effects of mitochondria-targeted antioxidants in a Parkinson’s ...
Costa , I.; Benfeito , S.; Silva , V.; Cagide , F.; Borges , F.; Remião , F.; Silva , R.Background: Parkinson’s disease (PD) is a neurodegenerative disease with early prominent death of dopaminergic neurons in the substantia nigra pars compacta, concurrently with Lewys body formation, iron accumulation, oxidative stress and ferroptosis[1–3]. Since there is no effective therapy capable of stopping/delaying disease progression, phenolic acids such as hydroxycinnamic and hydroxybenzoic acids (HCA and...
New 8-hydroxyquinoline derivatives as promising therapeutic approaches targetin...
Marques-Oliveira , R.; Alfenim, A. R.; Soares , P.; Borges , F.; Remião, F.; Fernandes, C.; Silva , R.Background: Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis are recognized as the most prevalent neurodegenerative diseases (NDs), presenting a huge burden for society. These diseases share common pathophysiological mechanisms, such oxidative stress, dysfunction in iron metabolism, ferroptosis, and protein misfolding [1-4]. Given their powerful metal chelating and antioxidant propert...