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Caffeine has a dual influence on NMDA receptor–mediated glutamatergic transmiss...
Silva Martins, Robertta; Rombo, Diogo M.; Gonçalves-Ribeiro, Joana; Meneses, Carlos; Borges-Martins, Vladimir P. P.; Ribeiro, Joaquim A.; Vaz, Sandra H.Caffeine, a stimulant largely consumed around the world, is a non-selective adenosine receptor antagonist, and therefore caffeine actions at synapses usually, but not always, mirror those of adenosine. Importantly, different adenosine receptors with opposing regulatory actions co-exist at synapses. Through both inhibitory and excitatory high-affinity receptors (A1R and A2R, respectively), adenosine affects NMDA...
Date: 2020
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Origin: Repositório da Universidade de Lisboa