12 documents found, page 1 of 2

Synthesis of novel pyrazolo[3,4-b]quinolinebisphosphonic acids and an unexpecte...

Novel pyrazolo[3,4-b]quinoline α-ketophosphonic and hydroxymethylenebisphosphonic acid compounds were synthesized using different methodologies, starting from 2-chloro-3-formylquinoline 1. New phosphonic acid compounds were obtained as N-1 derivatives with a side chain with 1 or 3 (n = 1 or 3) methylene groups. All phosphonic acid compounds and their corresponding ester and carboxylic acid precursors were fully ...

Synthesis of novel pyrazolo[3,4-b]quinoline-bisphosphonic acids and an unexpect...

ABSTRACT: Novel pyrazolo[3,4-b]quinoline alpha-ketophosphonic and hydroxymethylenebisphosphonic acid compounds were synthesized using different methodologies, starting from 2-chloro-3-formylquinoline 1. New phosphonic acid compounds were obtained as N-1 derivatives with a side chain with 1 or 3 (n = 1 or 3) methylene groups. All phosphonic acid compounds and their corresponding ester and carboxylic acid precurs...

Novel bisphosphonates derived from 1H-indazole, 1H-pyrazolo[3,4-b]pyridine and ...

Novel tetraethyl ethylene-1,1-bisphosphonate esters derived from 1H-indazole, 1H-pyrazolo[3,4-b]pyridine, and 1H-yrazolo[3,4- b]quinoline were synthesized by a Michael addition reaction of tetraethyl ethylidene-1,1-bisphosphonate with the corresponding heterocycle, using conventional heating and microwave-assisted methods. The microwave-assisted method provides shorter reaction times and better yields. The hydr...

Novel Bisphosphonates Derived from 1H-Indazole, 1H-Pyrazolo[3,4-b]Pyridine, and...

Novel tetraethyl ethylene-1,1-bisphosphonate esters derived from 1H-indazole, 1H-pyrazolo[3,4-b]pyridine, and 1H-pyrazolo[3,4-b]quinoline were synthesized by a Michael addition reaction of tetraethyl ethylidene-1,1-bisphosphonate with the corresponding heterocycle, using conventional heating and microwave-assisted methods. The microwave-assisted method provides shorter reaction times and better yields. The hydr...

Validation of the Comprehensive ICF Core Set for obstructive pulmonary diseases...

This study aimed to validate the Comprehensive International Classification of Functioning, Disability and Health (ICF) Core Set for Obstructive Pulmonary Diseases (OPD) from the perspective of patients with COPD.

New 1-Hydroxy-1,1-bisphosphonates derived from 1H-Pyrazolo[3,4-b]pyridine: Synt...

A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono- and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the propo...

New 1-Hydroxy-1,1-bisphosphonates Derived from 1H-Pyrazolo[3,4-b]pyridine: Synt...

A partir da 2-cloro-3-formilpiridina, sintetizou-se uma série de compostos derivados da 1H-pirazolo[3,4-b]piridina de modo a obter os correspondentes 1-hidroxibisfosfonatos, uma classe de compostos com potencial interesse biológico. Os dados espectroscópicos foram utilizados na caracterização de todos os compostos e na identificação dos regioisômeros N-1 e N-2, e dos derivados mono- e bisfosfonatos. Estudos de ...

New 1-Hydroxy-1,1-bisphosphonates derived from 1H-Pyrazolo[3,4-b]pyridine: Synt...

A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono- and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the propo...

UNEXPECTED INTRAMOLECULAR CYCLIZATION AND PHOSPHONATION OF A PYRAZOLO[3,4-b]QUI...

The pyrazoloquinolines are an extensively studied group of compounds which present a large number of applications in medicinal chemistry, such as anticancer, antianxiety, anti-inflammatory, antiasthmatic and antiviral activities.[1,2] Also, they have been classified as a promising material for optoelectronics due to their highly fluorescent properties.[2] Bisphophonates (BPs) are potent antiresorptive agents us...

New substituted indazole and condensed pyrazole bisphosphonetes