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PD-1 Expression in Endometriosis
Reis, José Lourenço; Martins, Catarina; Ângelo-Dias, Miguel; Rosa, Natacha Nurdine; Borrego, Luís Miguel; Lima, JorgeBackground: Endometriosis, believed by many to be rooted in immunology, is a chronic disease. Upregulation of programmed cell death protein 1 (PD-1) in immune cells may compromise their defensive function, a mechanism demonstrated in the context of cancer spread. This study aims to explore the potential involvement of PD-1 in the pathophysiology and progression of endometriosis. A total of 62 patients who under...
The Role of NK and T Cells in Endometriosis
Reis, José Lourenço; Rosa, Natacha Nurdine; Reis, José; Martins, Catarina; Ângelo-Dias, Miguel; Rosa, Natacha Nurdine; Borrego, Luís Miguel; Lima, JorgeEndometriosis, a debilitating condition, affects one in ten women of reproductive age. Its pathophysiology remains unclear, though deficiencies in immune surveillance are thought to create an environment conducive to the evasion of ectopic endometrial cells from the immune system. Our research explores the immunological impact of endometriosis both locally and systemically, emphasizing natural killer (NK) and T...