13 documents found, page 1 of 2
Case report
Vilhais, Guilherme; Alpuim Costa, Diogo; Fontes-Sousa, Mário; Ribeiro, Pedro Casal; Martinho, Filipa; Botelho de Sousa, CarolinaPublisher Copyright: Copyright © 2024 Vilhais, Alpuim Costa, Fontes-Sousa, Ribeiro, Martinho, Botelho de Sousa, Santos, Negreiros, Canastra, Borralho, Guia Pereira, Marçal, Germano Sousa, Chaleira, Rocha, Calhau and Faria.; Locally advanced breast cancer poses significant challenges to the multidisciplinary team, in particular with hormone receptor (HR) positive, HER2-negative tumors that classically yield lowe...
Sialyl LewisX/A and Cytokeratin Crosstalk in Triple Negative Breast Cancer
Pascoal, Carlota; Carrascal, Mylène A.; Barreira, Daniela F.; Lourenço, Rita A.; Granjo, Pedro; Grosso, Ana R.; Borralho, Paula; Braga, Sofiaproject LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. Publisher Copyright: © 2023 by the authors.; Triple-negative breast cancer (TNBC) encompasses multiple entities and is generally highly aggressive and metastatic. We aimed to determine the clinical and biological relevance of Sialyl-Lewis X and A (sLeX/A)—a fucosylated glycan involved in metastasis—in TNBC. Here, we stu...
Identification of biomarkers predictive of metastasis development in early-stag...
Peixoto, Carolina; Lopes, Marta B.; Martins, Marta; Casimiro, Sandra; Sobral, Daniel; Grosso, Ana Rita; Abreu, Catarina; Macedo, DanielaPublisher Copyright: © 2023, The Author(s).; Colorectal cancer (CRC) is the third most common cancer and the second most deathly worldwide. It is a very heterogeneous disease that can develop via distinct pathways where metastasis is the primary cause of death. Therefore, it is crucial to understand the molecular mechanisms underlying metastasis. RNA-sequencing is an essential tool used for studying the transcr...
Predictive and Therapeutic Implications of a Novel PLCγ1/SHP2-Driven Mechanism ...
Cruz-Duarte, Raquel; de Almeida, Cátia Rebelo; Negrão, Magda; Fernandes, Afonso; Borralho, Paula; Sobral, Daniel; Gallego-Paez, Lina M.; Machado, DanielP. Borralho reports grants from Roche and Novartis, as well as personal fees from Bayer and AstraZeneca outside the submitted work. D. Machado reports personal fees from Amgen and Merck outside the submitted work. H. Mansinho reports grants from AstraZeneca; nonfinancial support from AstraZeneca; and personal fees from Roche, Pfizer, Pierre Fabre, Incyte, BMS, Novartis, Amgen, Servier, Merck Serono, and Grunent...
Assessment of a Large-Scale Unbiased Malignant Pleural Effusion Proteomics Stud...
Zahedi, Sara; AS, Carvalho; Ejtehadifar, Mostafa; Beck, Hans C.; Rei, Nádia; Luis, Ana; Borralho, Paula; Bugalho, António; Matthiesen, RuneFunding Information: R.M. is supported by Fundação para a Ciência e a Tecnologia (CEEC position, 2019–2025 investigator). This article is a result of the projects (iNOVA4Health—UIDB/04462/2020), supported by Lisboa Portugal Regional Operational Programme (Lisboa2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This work is also funded by FEDER funds thr...
Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal can...
Sobral, Daniel; Martins, Marta; Kaplan, Shannon; Golkaram, Mahdi; Salmans, Michael; Khan, Nafeesa; Vijayaraghavan, Raakhee; Casimiro, SandraWe thank João Neto and remaining Computational Multi-Omics Lab members at UCIBIO for their helpful comments and suggestions. © 2022. The Author(s).; Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in ...
Next-Generation Sequencing in Breast Cancer Management
Batista, Marta Vaz; Alpuim Costa, Diogo; Borralho, Paula; Braga, SofiaPublisher Copyright: © 2021 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).; The clinicopathological breast cancer subtypes are used in clinical practice to better anticipate biological behaviour and guide systemic treatment strategy. In the adjuvant setting, genomic assay recurrence scores becam...
Human Microbiota and Breast Cancer—Is There Any Relevant Link?—A Literature Rev...
Alpuim Costa, Diogo; Nobre, José Guilherme; Batista, Marta Vaz; Ribeiro, Catarina; Calle, Catarina; Cortes, Alfonso; Marhold, Maximilian; Negreiros, IdaBreast cancer (BC) is the most common malignancy and the second cause of cancer-specific death in women from high-income countries. Recently, gut microbiota dysbiosis emerged as a key player that may directly and/or indirectly influence development, treatment, and prognosis of BC through diverse biological processes: host cell proliferation and death, immune system function, chronic inflammation, oncogenic sign...
Expression of hla-dr in cytotoxic t lymphocytes
Saraiva, Diana P.; Azeredo-Lopes, Sofia; Antunes, Ana; Salvador, Rute; Borralho, Paula; Assis, Beatriz; Pereira, Isabel L.; Seabra, Zita; Negreiros, IdaFunding Information: Funding: This work was supported by Terry Fox Research Grant 2019 from Liga Portuguesa Contra o Cancro; Clinical Research Prize 2018 from Consortium Tagus Tank; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015 for DPS and SFRH/BD/148422/2019 for RS) and iNOVA4Health (UIDB/04462/2020, DAI/2019/46). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.; Neoadju...
Carcinoembryonic antigen is a sialyl Lewis x/a carrier and an E‑selectin ligand...
Ferreira, Inês Gomes; Carrascal, Mylène; Mineiro, A. Gonçalo; Bugalho, António; Borralho, Paula; Silva, Zélia; Dall'Olio, Fabio; Videira, Paula A.LPCC/Pfizer 2011. Tagus TANK award 2018 (grant no. 1/2018). SFRH/BD/100970/2014 SFRH/BPD/108686/2015; The formation of distant metastasis resulting from vascular dissemination is one of the leading causes of mortality in non-small cell lung cancer (NSCLC). This metastatic dissemination initiates with the adhesion of circulating cancer cells to the endothelium. The minimal requirement for the binding of leukocyt...