24 documents found, page 1 of 3
Tumor-infiltrating T cells in skin basal cell carcinomas and squamous cell carc...
Cunha, Daniela; Neves, Marco; Silva, Daniela; Silvestre, Ana Rita; Borralho, Paula; Arrobas, Fernando; Ribot, Julie; Ferreira, Fernando; Moita, Luís F.Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are high-incidence, non-melanoma skin cancers (NMSCs). The success of immune-targeted therapies in advanced NMSCs led us to anticipate that NMSCs harbored significant populations of tumor-infiltrating lymphocytes with potential anti-tumor activity. The main aim of this study was to characterize T cells infiltrating NMSCs. Flow cytometry and immuno...
Case report: Primary CDK4/6 inhibitor and endocrine therapy in locally advanced...
Vilhais, Guilherme; Alpuim Costa, Diogo; Fontes-Sousa, Mário; Ribeiro, Pedro Casal; Martinho, Filipa; Botelho de Sousa, CarolinaLocally advanced breast cancer poses significant challenges to the multidisciplinary team, in particular with hormone receptor (HR) positive, HER2-negative tumors that classically yield lower pathological complete responses with chemotherapy. The increasingly significant use of CDK 4/6 inhibitors (CDK4/6i) plus endocrine therapy (ET) in different breast cancer settings has led to clinical trials focusing on thi...
Expression of NORAD correlates with breast cancer aggressiveness and protects b...
Alves-Vale, Catarina; Capela, Ana Maria; Tavares-Marcos, Carlota; Domingues-Silva, Beatriz; Pereira, Bruno; Santos, Francisco; Gomes, Carla PereiraThe recently discovered human lncRNA NORAD is induced after DNA damage in a p53-dependent manner. It plays a critical role in the maintenance of genomic stability through interaction with Pumilio proteins, limiting the repression of their target mRNAs. Therefore, NORAD inactivation causes chromosomal instability and aneuploidy, which contributes to the accumulation of genetic abnormalities and tumorigenesis. NO...
Portuguese Consensus Recommendations for Next-Generation Sequencing of Lung Can...
R. Teixeira, Manuel; Oliveira, Júlio; Borralho, Paula; O. Fernandes, Maria Gabriela; Almodovar, Teresa; Fernandes, Isabel; Macedo, DanielaNext-generation sequencing (NGS) has been implemented in clinical oncology for diagnosis, prognosis, and therapeutic guidance. Among the various NGS applications in molecular oncology, we focused on the following topics: laboratory standards for targeted gene panels (somatic mutations) and therapeutic guidance based on NGS of lung cancer and rare cancers, namely sarcomas and cancers of unknown primary. Multiple...
Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal can...
Sobral, Daniel; Martins, Marta; Kaplan, Shannon; Golkaram, Mahdi; Salmans, Michael; Khan, Nafeesa; Vijayaraghavan, Raakhee; Casimiro, SandraColorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in CRC outcome is not fully understood. Therefore, we assessed intra- and inter-tumor heterogeneity of a prospective cohort of 136 CRC samples. We demon...
Predictive and therapeutic implications of a novel PLCγ1/SHP2-driven mechanism ...
Duarte, Raquel; Rebelo de Almeida, Cátia; Negrão, Magda; Fernandes, Afonso; Borralho, Paula; Sobral, Daniel; Gallego-Paez, Lina M.; Machado, DanielPurpose: Cetuximab is an EGFR-targeted therapy approved for the treatment of RAS wild-type (WT) metastatic colorectal cancer (mCRC). However, about 60% of these patients show innate resistance to cetuximab. To increase cetuximab efficacy, it is crucial to successfully identify responder patients, as well as to develop new therapeutic approaches to overcome cetuximab resistance. Experimental design: We evaluated...
The Landscape of Non-Melanoma Skin Cancer in Portugal
Ascenção, Raquel; Silva, João Maia; Borralho, Paula; Correia, Miguel; Correia, Osvaldo; Costa, João; Machado, Tiago; Mainoli, Beatrice; Sampaio, FilipaIntroduction: Non-melanoma skin cancer (NMSC) includes several types of skin cancer, with the most common types of tumors being basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The current study aims to describe the landscape of NMSC in Portugal, based on real world data from both the public and private sectors.Methods: Two sub-studies are included in this work. In sub-study one, hospital episode s...
Human Microbiota and Breast Cancer-Is There Any Relevant Link?-A Literature Rev...
Alpuim Costa, Diogo; Nobre, José Guilherme; Batista, Marta Vaz; Ribeiro, Catarina; Calle, Catarina; Cortes, Alfonso; Marhold, Maximilian; Negreiros, IdaBreast cancer (BC) is the most common malignancy and the second cause of cancer-specific death in women from high-income countries. Recently, gut microbiota dysbiosis emerged as a key player that may directly and/or indirectly influence development, treatment, and prognosis of BC through diverse biological processes: host cell proliferation and death, immune system function, chronic inflammation, oncogenic sign...
Human microbiota and breast cancer: is there any relevant link? A literature re...
Costa, Diogo Alpuim; Nobre, José Guilherme; Batista, Marta Vaz; Ribeiro, Catarina; Calle, Catarina; Cortes, Alfonso; Marhold, Maximilian; Negreiros, IdaBreast cancer (BC) is the most common malignancy and the second cause of cancer-specific death in women from high-income countries. Recently, gut microbiota dysbiosis emerged as a key player that may directly and/or indirectly influence the development, treatment, and prognosis of BC through diverse biological processes: host cell proliferation and death, immune system function, chronic inflammation, oncogenic ...
Human microbiota and breast cancer : is there any relevant link? A literature r...
Alpuim Costa, Diogo; Gonçalves Nobre, José Guilherme; Batista, Marta Vaz; Ribeiro, Catarina; Calle, Catarina; Cortes, Alfonso; Marhold, MaximilianBreast cancer (BC) is the most common malignancy and the second cause of cancer-specific death in women from high-income countries. Recently, gut microbiota dysbiosis emerged as a key player that may directly and/or indirectly influence development, treatment, and prognosis of BC through diverse biological processes: host cell proliferation and death, immune system function, chronic inflammation, oncogenic sign...