44 documents found, page 1 of 5
Added value of lymphocyte subpopulations in the classification of Sjögren's syn...
Barcelos, F; Brás-Geraldes, C; Martins, C; Papoila, AL; Monteiro, R; Cardigos, J; Madeira, N; Alves, N; Vaz-Patto, J; Cunha-Branco, J; Borrego, LMSjögren's Syndrome (SjS) is a chronic systemic immune-mediated inflammatory disease characterized by lymphocytic infiltration and consequent lesion of exocrine glands. SjS diagnosis and classification remains a challenge, especially at SjS onset, when patients may have milder phenotypes of the disease or uncommon presentations. New biomarkers are needed for the classification of SjS, thus, we aimed to evaluate ...
Added Value of Lymphocyte Subpopulations in the Classification of Sjögren's Syn...
Barcelos, F; Brás-Geraldes, C; Martins, C; Papoila, AL; Monteiro, R; Cardigos, J; Madeira, N; Alves, N; Vaz-Patto, J; Cunha-Branco, J; Borrego, LMSjögren's Syndrome (SjS) is a chronic systemic immune-mediated inflammatory disease characterized by lymphocytic infiltration and consequent lesion of exocrine glands. SjS diagnosis and classification remains a challenge, especially at SjS onset, when patients may have milder phenotypes of the disease or uncommon presentations. New biomarkers are needed for the classification of SjS, thus, we aimed to evaluate ...
Association between EBV serological patterns and lymphocytic profile of SjS pat...
Barcelos, F; Martins, C; Monteiro, R; Cardigos, J; Prussiani, T; Sítima, M; Alves, N; Vaz-Patto, JA; Cunha-Branco, J; Borrego, LMSjögren's syndrome (SjS) is characterized by lymphocytic infiltration of exocrine glands, i.e. autoimmune epithelitis. Lymphocytes are central in SjS pathogenesis, with B-cell hyperactivity mediated by T-cells. B-cells are main targets of Epstein-Barr virus (EBV) infection, a frequently-suggested trigger for SjS. We aimed to evaluate how the EBV infection modulates B and T-cell subsets in SjS, including as cont...
Lymphocyte Subpopulations in Sjögren’s Syndrome Are Distinct in Anti-SSA-Positi...
Barcelos, F; Martins, C; Madeira, N; Dias, M; Cardigos, J; Alves, N; Vaz-Patto, J; Cunha-Branco, J; Borrego, LMObjectives: Sjögren's syndrome (SjS) patients exhibit great phenotypical heterogeneity, reinforced by the positiveness of anti-SSA antibody. We aimed to evaluate lymphocyte subpopulations in SSA-positive (SSA+SjS) and SSA-negative (SSA-SjS) SjS patients, Sicca patients, and healthy controls (HC), and to investigate associations between lymphocyte subpopulations and disease activity in SjS. Methods: According to...
Novel IL2RG Mutation Causes Leaky TLOWB+NK+ SCID With Nodular Regenerative Hype...
Neves, JF; Martins, C; Cordeiro, AI; Neves, C; Plagnol, V; Curtis, J; Fabre, M; Bibi, S; Borrego, LM; Moshous, D; Nejentsev, S; Gilmour, KX-linked severe combined immunodeficiency disease (SCID) is caused by mutations in the interleukin (IL)-2 receptor γ (IL2RG) gene and patients usually present with a TBNK SCID phenotype. Nevertheless, a minority of these patients present with a TBNK phenotype, similar to the IL-7R-deficient patients. We report a patient with a novel missense p.Glu297Gly mutation in the IL2RG gene presenting with a leaky TBNK SC...
Serum markers of B-cell activation in pregnancy during late gestation, delivery...
Lima, J; Cambridge, G; Vilas-Boas, A; Martins, C; Borrego, LM; Leandro, MB cells are vital for the normal evolution of pregnancy due to their humoral and possible regulatory activities. Our group and others have documented that circulating B-cell subsets undergo changes from normal late pregnancy to the postpartum period. However, the underlying mechanisms are poorly understood. Therefore, this study examined the degree of B-cell activation in normal pregnancy by analyzing the level...
Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa
Neves, JF; Doffinger, R; Barcena-Morales, G; Martins, C; Papapietro, O; Plagnol, V; Curtis, J; Martins, M; Kumararatne, D; Cordeiro, AI; Neves, CBackground: The auto-inflammation and phospholipase Cγ2 (PLCγ2)-associated antibody deficiency and immune dysregulation (APLAID) syndrome is a rare primary immunodeficiency caused by a gain-of-function mutation S707Y in the PLCG2 gene previously described in two patients from one family. The APLAID patients presented with early-onset blistering skin lesions, posterior uveitis, inflammatory bowel disease (IBD) a...
Association Between Memory B-Cells and Clinical and Immunological Features of P...
Barcelos, F; Martins, C; Papoila, A; Geraldes, C; Cardigos, J; Nunes, G; Lopes, T; Alves, N; Vaz-Patto, J; Branco, J; Borrego, LMB-cells play a pivotal role in primary Sjögren's syndrome (pSS) pathogenesis. We aim to (1) evaluate the distribution of B-lymphocyte subpopulations in pSS and Sicca patients, (2) establish cut-off points that discriminate pSS from controls, (3) evaluate the association between memory B-cells and phenotypic features in pSS. We included 57 pSS patients, 68 Sicca and 24 healthy controls. Circulating B-cells were ...
Immune Cell and Cytokine Patterns in Children with Type 1 Diabetes Mellitus Und...
Fitas, AL; Martins, C; Borrego, LM; Lopes, L; Jörns, A; Lenzen, S; Limbert, CObjective: Type 1 diabetes (T1D) develops in distinct stages, before and after disease onset. Whether the natural course translates into different immunologic patterns is still uncertain. This study aimed at identifying peripheral immune patterns at key time-points, in T1D children undergoing remission phase. Methods: Children with new-onset T1D and healthy age and gender-matched controls were recruited at a pe...
Characterization of B cells in healthy pregnant women from late pregnancy to po...
Lima, J; Martins, C; Leandro, MJ; Nunes, G; Sousa, MJ; Branco, J; Borrego, LMBACKGROUND: B cells play a role in pregnancy due to their humoral and regulatory activities. To our knowledge, different maturational stages (from transitional to memory) of circulating B cell subsets have not yet been characterized (cell quantification and phenotype identification) in healthy pregnant women. Thus, the objective of our study was to characterize these subsets (as well as regulatory B cells) from...