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Local adaptation in populations of Mycobacterium tuberculosis endemic to the In...

Menardo, Fabrizio; Rutaihwa, Liliana K; Zwyer, Michaela; Borrell, Sonia; Comas, I?aki; Concei??o, Emilyn Costa; Cascolla, Mireia; Cox, Hellen

This work was supported by the Swiss National Science Foundation (grants 310030_188888, CRSII5_177163, IZRJZ3_164171 and IZLSZ3_170834) and the European Research Council (309540?EVODRTB and 883582-ECOEVODRTB); Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology. Basel, Switzerland / University of Basel. Basel, Switzerland.; Swiss Tropical and Public Health Instit...

Date: 2021   |   Origin: Oasisbr

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geograp...

Stucki, David; Brites, Daniela; Jeljeli, Leila; Coscolla, Mireia; Liu, Qingyun; Trauner, Andrej; Fenner, Lukas; Rutaihwa, Liliana; Borrell, Sonia

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, sugges...


Mycobacterium tuberculosis lineage 4 comprises globally distributed and geograp...

Stucki, David; Brites, Daniela; Jeljeli, Leïla; Coscolla, Mireia; Liu, Qingyun; Trauner, Andrej; Fenner, Lukas; Rutaihwa, Liliana; Borrell, Sonia

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, sugges...


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