2 documents found, page 1 of 1
Precision non-implantable neuromodulation therapies: a perspective for the depr...
Borrione, Lucas; Bellini, Helena; Razza, Lais Boralli; Ávila, Ana G.; Baeken, Chris; Brem, Anna-Katharine; Busatto, Geraldo; Carvalho, Andre F.Current first-line treatments for major depressive disorder (MDD) include pharmacotherapy and cognitive-behavioral therapy. However, one-third of depressed patients do not achieve remission after multiple medication trials, and psychotherapy can be costly and time-consuming. Although non-implantable neuromodulation (NIN) techniques such as transcranial magnetic stimulation, transcranial direct current stimulati...
Nonverbal behaviors are associated with increased vagal activity in major depre...
Fernandes, Raquel A.; Fiquer, Juliana T.; Gorenstein, Clarice; Razza, Lais Boralli; Fraguas Jr, Renério; Borrione, Lucas; Benseñor, Isabela M.Background Major depressive disorder (MDD) is associated with impairments in nonverbal behaviors (NVBs) and vagal activity. The polyvagal theory proposes that vagal activity regulates heart rate and NVBs by modulating a common anatomically and neurophysiologically discrete social engagement system. However, the association between these putative endophenotypes has not yet been explored. We hypothesize that in M...