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Targeting senescent cells improves functional recovery after spinal cord injury
Paramos-de-Carvalho, Diogo; Martins, Isaura; Cristóvão, Ana Margarida; Dias, Ana Filipa; Silva, Dalila; Pereira, Telmo; Chapela Pires, DianaPersistent senescent cells (SCs) are known to underlie aging-related chronic disorders, but it is now recognized that SCs may be at the center of tissue remodeling events, namely during development or organ repair. In this study, we show that two distinct senescence profiles are induced in the context of a spinal cord injury between the regenerative zebrafish and the scarring mouse. Whereas induced SCs in zebra...
Innovative therapies for spinal cord injury : a zebrafish approach
Chapela Pires, DianaSpinal cord injury (SCI) is a debilitating condition that affects millions of people worldwide. It leads to devastating motor and sensory dysfunctions and elicits cardiac and respiratory alterations, bladder and bowel dysfunction, as well as, sexual dysfunction and other complications. This complex neurological condition has a huge impact on the health, quality and life expectancy, thus constituting a high soci...
Tapentadol prevents motor impairments in a mouse model of dyskinesia
Vaz, Rita; Chapela Pires, Diana; Coelho, Joana E; Lopes, Luisa V.; Ferreira, Joaquim J; Afonso, Nuno D.; Sousa, Sara; Outeiro, TiagoThe motor features in Parkinson's disease (PD) are associated with the degeneration of dopaminergic cells in the substantia nigra in the brain. Thus, the gold-standard in PD therapeutics still consists of dopamine replacement with levodopa. However, as the disease progresses, this therapeutic option becomes less effective and can be accompanied by levodopa-induced complications. On the other hand, several other...