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Contributo da PET/CT com Fluorocolina-F18 na Radioterapia Externa do Carcinoma ...

Lapa, Paula; Jacobetty, Miguel; Marques, Margarida; Costa, Gracinda; Borrego, Margarida; Lima, João Pedroso

Objetivo: A radioterapia é uma opção terapêutica no carcinoma da próstata. Pretendemos avaliar o contributo da PET/CT com Fluorocolina-F18(FCH-F18) na identificação dos doentes com indicação para essa estratégia terapêutica e o impacto no seu planeamento. Material e Métodos: Analisámos retrospetivamente 282 PET/CT com FCH-F18. Seleccionámos 187 doentes sem antecedentes de radioterapia prévia (41 estadiamentos i...

Date: 2017   |   Origin: Acta Radiológica Portuguesa

A Utilidade da PET/CT com FDG-F18 nasVasculites Sistémicas

Saraiva, Tiago Manuel; Lapa, Paula; Costa, Gracinda; Lima, João Pedroso de

As vasculites sistémicas são um conjunto heterogéneo de patologias, cuja história natural tem sido modificada significativamente pelas terapêuticas atuais. Podem envolver os pequenos, médios e grandes vasos e uma vez que um número significativo de doentes apresenta sintomatologia atípica, o seu diagnóstico precoce é muitas vezes protelado. Efetuou-se uma revisão da literatura com o objetivo de avaliar a utilida...

Date: 2017   |   Origin: Acta Radiológica Portuguesa

Avaliação de hipóxia tumoral por PET/CT com fluoromisonidazol(18 F) no planeame...

Lapa, Paula; Jacobetty, Miguel; Teixeira, Tânia; Silva, Rodolfo; Saraiva, Tiago; Ferreira, Rui; Costa, Gracinda; Borrego, Margarida; Lima, João Pedroso

A hipóxia está frequentemente presente nos tumores sólidos malignos, encontrando-se associada a agressividade tumoral e a resistência à terapêutica. A sua detecção tem elevada importância clínica porque o prognóstico das lesões malignas com baixos níveis de oxigenação é desfavorável. O Fluoromisonidazol (18 F) (FMISO-F18) é um radiofármaco desenvolvido com o objectivo de identificar hipóxia tumoral. Há forte ev...

Date: 2017   |   Origin: Acta Radiológica Portuguesa

18F‐Fluorocholine PET/CT in prostate cancer initial staging

Lapa, Paula; Silva, Rodolfo; Saraiva, Tiago; Figueiredo, Arnaldo; Ferreira, Rui; Costa, Gracinda; Pedroso Lima, João

AimIn the evaluation of prostate cancer, clinical nomograms are commonly used to predict the probability of lymphatic and extra‐nodal spread. Those nomograms may suggest the presence and the extension of this cancer but do not allow a clear distinction between loco‐regional and distant disease. In this study, it was intended to evaluate the usefulness of 18F‐Fluorocoline positron emission tomography/computed to...

Date: 2017   |   Origin: Acta Urológica Portuguesa

Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with ...

Lapa, Paula; Saraiva, Tiago; Silva, Rodolfo; Marques, Margarida; Costa, Gracinda; Lima, João Pedroso

Introduction: The 18F-NaF positron emission tomography/computed tomography is being considered as an excellent imaging modalityfor bone metastases detection. This ability was compared with other imaging techniques.Material and Methods: We retrospectively evaluated 114 patients who underwent 18F-NaF positron emission tomography/ computed tomography. Of these, 49 patients also had bone scintigraphy, 61 18F-FDG po...

Date: 2017   |   Origin: Acta Médica Portuguesa

Assessment of iodine-131 in the urine of the patient’s family members after dif...

Raminhas Carapinha, Maria João; Costa, Gracinda; Ferreira, Teresa C.; Salgado, Lucília; Carvalho, Inês; Sofia, Monica; Isidoro, Jorge; Rézio, Teresa

Introduction - The aim is to evaluate the internal exposure of the family members (FMs) of the patients (PATs) undergoing iodine-131 (131I) thyroid cancer (TC) therapy and quantify the amount of 131I in the FMs, excreted through the urinary. Methods - An observational study with convenience sampling was performed, including 25 PATs and 34 FMs. The PATs, who underwent 131I treatments for TC, were discharged from...


131I therapy in thyroid cancer and benign thyroid diseases: personal dose equiv...

Raminhas Carapinha, Maria João; Costa, Gracinda; Ferreira, Teresa C.; Salgado, Lucília; Vaz, Sofia; Ferreira, Rui; Isidoro, Jorge; Rézio, Teresa

Introduction - The aim is to quantify the personal dose equivalent HP(10) in the family members (FMs) of the patients (PATs) undergoing iodine-131 thyroid cancer (TC) therapy and benign thyroid diseases (BTD) and to compare the HP(10) values of children and adults. Methods - An observational study with convenience sampling was performed, including 83 FMs (59% ♂) of 48 PATs (72.9% ♀). All FMs wore a whole body T...


PET/CT with 18F-Fluorocholine in Patients with Prostatic Cancer in Biochemical ...

Lapa, Paula; Silva, Rodolfo; Saraiva, Tiago; Figueiredo, Arnaldo; Ferreira, Rui; Costa, Gracinda; Lima, João Pedroso

Introduction: In prostate cancer, after therapy with curative intent, biochemical recurrence frequently occurs. The purpose of this study was to evaluate the impact of PET/CT with 18F-fluorocholine in restaging these patients and in their orientation, and to analyze the effect of the risk stratification, the values of PSA and the hormone suppression therapy, in the technique sensitivity. Material and Methods: R...

Date: 2016   |   Origin: Acta Médica Portuguesa

Thyroid Carcinoma in Children and Young Adults: Retrospective Review of 19 Cases

Saraiva, Joana; Ribeiro, Cristina; Melo, Miguel; Gomes, Leonor; Costa, Gracinda; Carrilho, Francisco

Introduction: Thyroid carcinoma is rare in children and young adults. Most of management guidelines are based in data from adult population. Several controversies remain regarding the aggressiveness of clinical presentation and therapeutic approach.Objective: To evaluate all differentiated thyroid carcinoma patients with less than 20 years-old at presentation reflecting the experience of our unit in relation to...

Date: 2013   |   Origin: Acta Médica Portuguesa

Left ventricular mechanical dyssynchrony in patients with impaired left ventric...

Ferreira, Maria João Vidigal; Silva, Rodolfo; Cabanelas, Nuno; Cunha, Maria João; Ramos, Domingos; Albuquerque, Anabela; Teixeira, Rogério

Introduction: Gated SPECT myocardial perfusion imaging (MPI) has been used to quantify mechanical dyssynchrony. Mechanical dyssynchrony appears to be related to response to cardiac resynchronization therapy. Objective: To evaluate the presence and predictors of mechanical dyssynchrony in patients with impaired left ventricular function (LVEF) ≤50%. Methods: The study included 143 consecutive patients referred f...


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