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Association between Matrix Metallopeptidase 9 Polymorphism and Breast Cancer Risk
Felizi,Rogério Tadeu; Veiga,Melissa Gonzalez; Carelli Filho,Ivo; Souto,Ricardo Peres do; Fernandes,César Eduardo; Oliveira,EmersonAbstract Objective Epidemiological studies have shown evidence of the effect of genetic variations in the pathogenesis of breast cancer and have suggested a relationship of the disease with genetic polymorphisms. Matrix metallopeptidase 9 (MMP-9) is a collagenase responsible for the degradation of type IV collagen, the major component of the basement membrane, and other essential extra cellular matrix component...
The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breas...
Veiga,Melissa Gonzalez; Felizi,Rogério Tadeu; Reis,Dayane Guerino; Carelli Filho,Ivo; Fernandes,Cesar Eduardo; Souto,Ricardo Peres do; Oliveira,EmersonAbstract Objective Epidemiological studies have shown evidence of the effect of sex hormones in the pathogenesis of breast cancer, and have suggested a relationship of the disease with variations in genes involved in estrogen synthesis and/or metabolism. The aim of the present study was to evaluate the association between the CYP3A4*1B gene polymorphism (rs2740574) and the risk of developing breast cancer. Meth...