2 documents found, page 1 of 1
Analysis of the immune response to Neospora caninum in a model of intragastric ...
Teixeira, L.; Botelho, A. S.; Batista, A. R.; Meireles, C. S.; Ribeiro, A.; Domingues, H. S.; Correia Da Costa, J. M.; Castro, António G.To study experimental Neospora caninum infection initiated at the gastrointestinal tract, Toll-like Receptor 4- and functional IL-12Rbeta2 chain-deficient C57BL/10 ScCr mice were challenged intragastrically with 5 x 10(6) N. caninum tachyzoites. All parasite-inoculated mice eventually died with disseminated infection. In contrast, immunocompetent BALB/c mice challenged with 1 x 10(7) N. caninum tachyzoites by t...
Neospora caninum: high susceptibility to the parasite in C57BL/10ScCr mice
Botelho, A. S.; Teixeira, L.; Costa, J. M. Correia da; Faustino, A. M. R.; Castro, António G.; Vilanova, M.C57BL/10ScCr mice, lack Toll-like receptor 4 and a functional Interleukin-12 receptor. Taking this into account, susceptibility of these mice to Neospora caninum infection was assessed comparatively to that of immunocompetent C57BL/10ScSn mice. C57BL/10ScCr mice inoculated intraperitoneally with 5 x 10(5) N. caninum tachyzoites showed a high Susceptibility to this parasite. All infected C57BL/10ScCr mice were d...