16 documents found, page 1 of 2
Prostate cancer treatment in Portugal: a nationwide analysis
Botelho, F; Lopes, R; Pina, F; Silva, C; Pacheco-Figueiredo, L; Lunet, NDifferent treatment options exist for localized prostate cancer. Treatments performed in high-volume hospitals are associated with better results. Our objective was to describe time trends in prostate cancer treatments in Portugal and case volume per hospital. We used the national database of diagnosis-related group of the Portuguese Central Administration of the Health System to describe the number of radical ...
Egg Freezing and the Impact of the COVID ‑19 Pandemic
Botelho, F; Costa, A; Jorge, S; Lopes, C; Sobral, DEgg freezing has evolved over the last decades, becoming an accepted and recognized technique for fertility preservation. This technique has various medical and non ‑medical indications and it is becoming an important step in overcoming age‑related de‑clines in fertility. Nonetheless, since it remains inadequately understood by the general public and medical professionals, raising its awareness is of vital impo...
Can serum endoglin be used to improve the diagnostic performance in prostate ca...
Pina, F; Ferro, A; Botelho, F; Manso, M; Dias, N; Figueiredo, G; Pereira, P; Dinis, P; Barros, H; Lunet, NPurpose: New biomarkers may contribute to avoid unnecessary biopsies resulting from the suboptimal performance of prostate-specific antigen (PSA) testing. This study aimed to assess serum endoglin as a prostate cancer (PCa) diagnostic tool among biopsy candidates. Methods: A total of 262 consecutive patients referred for prostate biopsy based on abnormal digital rectal examination and/or elevated total PSA (tPS...
[Smoking Cessation after Bladder Cancer Diagnosis]
Mota, P; Sousa, PM; Botelho, F; Carvalho-Dias, E; Cordeiro, A; Torres, JP; Morais, N; Anacleto, S; Lima, EINTRODUCTION: Smoking is an important risk factor for the development, recurrence and progression of bladder cancer. Our aim was to analyze smoking habits after diagnosis in bladder cancer patients. Additionally, we evaluated patient knowledge about smoking as a risk factor and the urologist role in promoting abstinence. MATERIAL AND METHODS: A cross-sectional, observational and descriptive study was performed ...
Endometrial Cancer Spheres Show Cancer Stem Cells Phenotype and Preference for ...
Carvalho, MJ; Laranjo, M; Abrantes, AM; Casalta-Lopes, J; Sarmento-Santos, D; Costa, T; Serambeque, B; Almeida, N; Gonçalves, T; Mamede, CThis study aimed to characterize endometrial cancer regarding cancer stem cells (CSC) markers, regulatory and differentiation pathways, tumorigenicity and glucose metabolism. Endometrial cancer cell line ECC1 was submitted to sphere forming protocols. The first spheres generation (ES1) was cultured in adherent conditions (G1). This procedure was repeated and was obtained generations of spheres (ES1, ES2 and ES3...
Can serum angiogenin be used to improve the diagnostic performance in prostate ...
Pina, F; Botelho, F; Lopes, T; Lopes, I; Figueiredo, G; Portugal, R; Ferro, A; Cruz, F; Barros, H; Lunet, NSeveral biomarkers have been studied to avoid unnecessary biopsies resulting from suboptimal performance of prostate-specific antigen (PSA) testing. We aimed to assess the use of serum angiogenin as a prostate cancer diagnostic tool among candidates for biopsy. We selected 252 patients referred for ultrasound-guided transrectal prostate biopsy on the basis of an abnormal digital rectal examination and/or elevat...
Endothelial function in patients with metabolic syndrome and erectile dysfuncti...
Tomada, N; Tomada, I; Botelho, F; Pacheco-Figueiredo, L; Lopes, T; Negrão, R; Pestana, M; Cruz, FErectile dysfunction (ED) is a highly prevalent disease whose aetiology is mostly vasculogenic. It is nowadays considered a marker of future cardiovascular events reflecting the underlying endothelial dysfunction, the common link with the metabolic syndrome (MetS). The recent association between MetS, endothelial dysfunction and peripheral artery disease, but not with coronary artery disease (CAD), suggests tha...
Metabolic syndrome and erectile dysfunction: Assessing the clinical and hemodyn...
Pacheco-Figueiredo, L; Neves, E; Coutinho, P; Botelho, F; Tomada, I; Tomada, NObjetivos Calcular a prevalência de fatores de risco cardiovascular, incluindo a síndrome metabólica (SM), numa série de doentes portugueses com disfunção erétil (DE) e quantificar o impacto individual e agregado dos mesmos, nos parâmetros hemodinâmicos e no grau de severidade reportada. Material e métodos Estudo de uma série de 408 doentes com DE seguidos em consulta de Urologia, no período 2008-2010. A SM foi...
Model-based patterns in prostate cancer mortality worldwide
Fontes, F; Severo, M; Castro, C; Lourenço, S; Gomes, S; Botelho, F; La Vecchia, C; Lunet, NBackground:Prostate cancer mortality has been decreasing in several high income countries and previous studies analysed the trends mostly according to geographical criteria. We aimed to identify patterns in the time trends of prostate cancer mortality across countries using a model-based approach.Methods:Model-based clustering was used to identify patterns of variation in prostate cancer mortality (1980–2010) a...
Does baseline total testosterone improve the yielding of prostate cancer screen...
Botelho, F; Pina, F; Figueiredo, L; Cruz, F; Lunet, NPrevious studies suggest an association between total testosterone (tT) and prostate cancer, but results are conflicting and it is not clear if accounting for the tT levels improves the yielding of patient selection for prostatic biopsy. We evaluated the potential for tT levels and the tT/total PSA (tPSA) ratio to be used as diagnostic tools for prostate cancer and its relation with cancer aggressiveness. We me...