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Blood count, endocrine, immunologic, renal, and hepatic markers in a case-contr...

Estarreja, João; Pimenta, Ana Clara; Botelho, João; Vilares, Arminda Maria; Mendes, José João; Rocha, João; Pinto, Rui; Mateus, Vanessa

Introduction: Periodontitis is a non-communicable chronic inflammatory disease with a systemic burden. Animal models of induced periodontitis help elucidate the mechanisms by which periodontal inflammation drives systemic effects. Studying this systemic involvement over longer follow-up periods may provide a strong foundation for future research on the association between diseases and periodontitis, particularl...


Non-Surgical Periodontal Treatment Impact on Subgingival Microbiome and Intra-O...

Izidoro, Catarina; Botelho, João; Machado, Vanessa; Reis, Ana Mafalda; Proença, Luís; Barroso, Helena; Alves, Ricardo; Mendes, José João

The purpose of this study was to characterize and compare subgingival microbiome before and after periodontal treatment to learn if any changes of the subgingival microbiome were reflected in intra-oral halitosis. We tested the hypothesis that intra-oral halitosis (Volatile sulfur compounds levels) correlates with corresponding subgingival bacterial levels before and after periodontal treatment. Twenty patients...


Searching for links between environmental and clinical mecA+ Staphylococcus aur...

Rocha, Jaqueline; Silva, Vanessa; Poeta, Patrícia; Botelho, João; Manaia, Célia M.

Staphylococcus aureus integrate the list of highly virulent and antibiotic resistant pathogens, mainly due to the mecA gene, associated with methicillin resistance. Given the ubiquity of this species, the aim of this study was to investigate whether closely related mecA+ S. aureus found in the environment can be also thrive as clinical isolates and if the respective accessory genome may suggest bacterial adapta...


Adverse pregnancy outcomes and maternal periodontal disease : an overview on me...

Machado, Vanessa; Ferreira, Madalena; Lopes, Luísa; Mendes, José João; Botelho, João

This umbrella review aims to appraise the methodological quality and strength of evidence on the association between maternal periodontitis and adverse pregnancy outcomes (APOs). PubMed, CENTRAL, Web-of-Science, LILACS, and Clinical Trials were searched until February 2023, without date or language restrictions. Two authors independently screened studies, extracted data, performed the risk-of-bias analysis, and...


Advancing universal oral health coverage via person-centred outcomes

Nascimento, Gustavo G.; Raittio, Eero; Machado, Vanessa; Leite, Fábio R. M.; Botelho, João

The World Health Organization member states proposed a comprehensive “Global Strategy on Oral Health,” which includes achieving universal oral health coverage by 2030. Challenges and barriers, including persistent inequalities, will hamper the achievement of universal oral health coverage. In low- and middle-income countries, the oral health of a large proportion of the population has been neglected, increasing...


An umbrella review of the evidence of sex determination procedures in forensic ...

Neves, João Albernaz; Antunes-Ferreira, Nathalie; Machado, Vanessa; Botelho, João; Proença, Luís; Quintas, Alexandre; Delgado, Ana Sintra

Sex determination in forensic dentistry is a major step towards postmortem profiling. The most widely recognized method is DNA, yet its application in the dental field of forensic sciences is still impractical. Depending on the conditions of the remains, teeth are often the only surviving organ. Some systematic reviews (SRs) have been recently produced; hence this umbrella review critically assesses their level...


An umbrella review of the evidence linking oral health and systemic noncommunic...

Botelho, João; Mascarenhas, Paulo; Viana, João; Proença, Luís; Orlandi, Marco; Leira, Yago; Chambrone, Leandro; Mendes, José João; Machado, Vanessa

Oral diseases are highly prevalent worldwide. Recent studies have been supporting a potential bidirectional association of oral diseases with systemic noncommunicable diseases (NCDs). Available evidence supports that people with NCDs have a greater prevalence of oral diseases particularly those with limited ability of oral self-care. Regarding the reverse relationship, the lines of evidence pointing out NCDs as...


Cross-cultural adaptation and validation of the Portuguese version of the psych...

Fidalgo, João; Botelho, João; Proença, Luís; Mendes, José João; Machado, Vanessa; Delgado, Ana Sintra

The aim of this study was to cross-culturally adapt and validate the psychosocial impact of dental esthetics questionnaire (PIDAQ) to the Portuguese language. The PIDAQ was culturally translated and adapted according to international guidelines. In this cross-sectional study, we enrolled 501 subjects in a population-based epidemiological survey conducted at the Egas Moniz Dental Clinic (Almada, Portugal) in Jun...


Cross-cultural adaptation and validation of the oral health values scale for th...

Machado, Vanessa; Mendonça, André; Proença, Luís; Mendes, José João; Botelho, João; McNeill, Daniel W.; Delgado, Ana Sintra

Background: To adapt and validate cross-culturally the Oral Health Values (OHVS) questionnaire to Portuguese language. Methods: The OHVS questionnaire was culturally translated and adapted according to international guidelines. We enrolled 280 patients in a population-based epidemiological survey conducted at the Egas Moniz Dental Clinic (Almada, Portugal). The participants answered the Portuguese version of th...


Chronological age range estimation of cervical vertebral maturation using Bacce...

Magalhães, Maria Inês; Machado, Vanessa; Mascarenhas, Paulo; Botelho, João; Mendes, José João; Delgado, Ana Sintra

Background: The timing of growth is a key factor for correct orthodontic treatment planning. Cervical vertebrae maturation (CVM) is no exception, although the reported chronological ages vary in the literature. Objective: We aimed to estimate the average chronological age for each Baccetti’s CVM staging. Search methods: Search on MEDLINE-PubMed, Scopus, LILACS, Google Scholar, Cochrane Central Register of Contr...


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