3 documents found, page 1 of 1
Hybrid Deep Brain Stimulation for Parkinson’s Disease and Dystonia Improves Sid...
Costa, Diogo; Calejo, Margarida; Vila-Chã, Nuno; Damásio, Joana; Silva, Carla; Procaci da Cunha, Eduardo; Botelho, Luís; Verdelho, AntónioIntroduction: Deep brain stimulation (DBS) in movement disorders does not always achieve optimal symptomatic control. Most common issues involve suboptimal electrode positioning and target stimulation and troublesome side effects limiting the therapeutic window. Recently approved implantable pulse generators (IPG) allow for pulse widths lower than 60 μs, increasing the therapeutic window, and current steering. ...
Late‐onset Levodopa Responsive Parkinsonism Due to Polymerase γ 1 Mutations
Calejo, Margarida; Vilarinho, Laura; Neiva, Raquel; Botelho, Luís; Ramalheira, João; Taipa, Ricardo; Melo‐Pires, Manuel; Lima, António BastosIntroduction: Polymerase γI (POLG) gene mutations may induce mitochondrial DNA (mtDNA) instability leading to its depletion or multiple deletions1 and causing a wide spectrum of multisystemic disorders. Commonly described phenotypes include AlpersHuttenlocher syndrome, childhood myocerebrohepatopathy, myoclonic epilepsy myopathy and sensory ataxia, mitochondrial recessive ataxia syndrome, sensory ataxia neuropa...
Inter-agent communication in a FIPA compliant intelligent distributed dynamic-i...
Botelho, Luís; Lopes, Rui; Sequeira, Manuel Menezes de; Almeida, Paulo; Martins, SérgioThis paper describes a traffic surveillance system as a particular case of the class of intelligent distributed dynamic-information systems (IDDIS). The Traffic Surveillance System is a vision-based FIPA compliant multi-agent system that uses the FIPA Agent Communication Language (ACL) and the FIPA Semantic Language (SL). The focus of the work is inter-agent communication and coordination. We have extended the ...