7 documents found, page 1 of 1
Fasciola hepatica extract induces cell death of mammalian cells
Ferreira, Stephanie; Fernandes, Rúben; Botelho, Mónica C.Fascioliasis is a neglected tropical disease that affects poor people from poor and developing countries. In the world, it has been estimated that at least 2.6 million people are affected with this disease. The International agency for Research on Cancer, states that O. viverrini and C. sinensis, also liver flukes, are considered as definitive causes of cholangiocarcinoma. However, fascioliasis caused by F. hep...
Commentary: Theileria Parasites Secrete a Prolyl Isomerase to Maintain Host Leu...
Fernandes, Rúben; Ferreira, Stephanie; Botelho, Mónica C.The genus Theileria comprises apicomplexan parasites that are tick-transmitted and infect ruminants with important trade and industry impact in endemic countries (1). Infectious agents build up elaborate machinery to work together by means of host cell pathways and takeover their genetic and epigenetic mechanisms to modify phenotypic status of host cells.
Commentary: Theileria Parasites Secrete a Prolyl Isomerase to Maintain Host Leu...
Fernandes, Ruben; Ferreira, Stephanie; Botelho, Mónica C.The genus Theileria comprises apicomplexan parasites that are tick-transmitted and infect ruminants with important trade and industry impact in endemic countries. Infectious agents build up elaborate machinery to work together by means of host cell pathways and takeover their genetic and epigenetic mechanisms to modify phenotypic status of host cells. Among the Apicomplexa phylum encompassing obligate intracell...
O papel dos estrogénios e vias de sinalização do recetor de estrogénio no cancr...
Botelho, Mónica C.O Schistosoma haematobium é um verme parasita que infecta mais de 100 milhões de indivíduos, principalmente no mundo em desenvolvimento. É o agente causador da schistosomose urogenital e tem sido associado com alta incidência de carcinoma de células escamosas da bexiga (SCC). A schistosomose haematobia também parece influenciar negativamente a fertilidade, particularmente a infertilidade feminina. Dado que os e...
Tumour-like phenotypes in urothelial cells after exposure to antigens from eggs...
Botelho, Mónica C.; Vale, N.; Gouveia, M.J.; Rinaldi, G.; Santos, J.; Santos, L.L.; Gomes, P.; Brindley, P.J.; Correia da Costa, José ManuelChronic infection with the blood fluke, Schistosoma haematobium, is associated with squamous cell carcinoma of the bladder. Previously, it has been shown that soluble extracts of mixed sex adult S. haematobium worms (SWAP) are tumourigenic, both in vitro and in vivo. In addition, oestrogen-related molecules in SWAP of S. haematobium down-regulate oestrogen receptors (ERs) alpha and beta in oestrogen responsive ...
Carcinogenic Ability of Schistosoma Haematobium Possibly through Oncogenic Muta...
Botelho, Mónica C.; Veiga, Isabel; Oliveira, Paula A.; Lopes, Carlos; Teixeira, Manuel; Costa, José M Correia da; Machado, José C.Schistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer, although why is not clear. Previously, we have used CD-1 mice to show that Schistosoma haematobium total antigen (Sh) has a carcinogenic ability. Sh intravesically instillation induced the development of several urothelial lesions, namely nodul...
Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma ...
Botelho, Mónica C.; Oliveira, Paula A.; Vieira, Paulo; Delgado, Maria de Lurdes; Lourenço, Ligia; Lopes, Carlos; Machado, José C .Golden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expected, but we found exclusively male worms, no female worms nor eggs. Interestingly we observed une...